Concentrations of PCDD/PCDFs in plasma of subjects living in the vicinity of a hazardous waste incinerator: follow-up and modeling validation

Chemosphere
Martí NadalJ L Domingo

Abstract

In 2007, the concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/PCDFs) were determined in plasma of non-occupationally exposed subjects living near the only hazardous waste incinerator (HWI) in Spain (Constantí, Tarragona County, Catalonia). These data were compared with the levels found in two previous surveys performed in 1998 (baseline) and 2002. The current mean PCDD/PCDF concentration in plasma was 9.36pg I-TEQg(-1) of lipid (range: 1.76-23.44pg I-TEQg(-1) of lipid). It means a significant reduction of the mean PCDD/PCDFs levels in plasma in comparison to the concentrations found in 1998 and 2002 (27.01 and 15.70pg I-TEQg(-1) of lipid, respectively). This important decrease agrees well with the notable reduction in the dietary intake of PCDD/PCDFs recently noted for the population of the same area (210.1pg I-TEQd(-1), 63.8pgWHO-TEQd(-1), and 27.8pgWHO-TEQd(-1), in 1998, 2002 and 2007, respectively). The current data were also used to predict theoretical PCDD/PCDF concentrations in plasma by executing a single-compartment empirically-based pharmacokinetic model on the basis of the daily intake of these pollutants by the local population.

References

Jan 5, 2001·Journal of Exposure Analysis and Environmental Epidemiology·G W Van der MolenW Slob
Jun 13, 2001·International Archives of Occupational and Environmental Health·J L DomingoF Neugebauer
Aug 13, 2002·International Archives of Occupational and Environmental Health·M SchuhmacherL Müller
Aug 29, 2002·Journal of Exposure Analysis and Environmental Epidemiology·Lesa L Aylward, Sean M Hays
Oct 26, 2002·Archives of Environmental Contamination and Toxicology·J L DomingoJ Corbella
Jul 10, 2003·Journal of Toxicology and Environmental Health. Part a·Sébastien FierensEdwin De Pauw
Aug 30, 2003·Chemosphere·Wakae MaruyamaJunko Nakanishi
Nov 13, 2004·Journal of Environmental Monitoring : JEM·Martí NadalJosé L Domingo
Jan 1, 2005·The Science of the Total Environment·Hsiu-Ling ChenChing-Chang Lee
Jan 7, 2005·Journal of Exposure Analysis and Environmental Epidemiology·M Carmen AgramuntJose L Domingo
Aug 2, 2005·Environmental Science & Technology·Catherine PirardJean-François Focant
Jun 13, 2006·Chemosphere·Danae CostopoulouLeondios Leondiadis
Jun 22, 2006·Archives of Environmental Contamination and Toxicology·J H LeemJ Kim
Jan 16, 2007·Chemosphere·Jürgen WittsiepeMichael Wilhelm
Feb 3, 2007·Environment International·José L Domingo, Ana Bocio
Mar 17, 2007·Inhalation Toxicology·Hui-Yan HuangFung-Chang Sung
Sep 14, 2007·Environment International·Kyoung-Soo KimJong-Guk Kim

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Citations

Feb 26, 2013·Environmental Health : a Global Access Science Source·Anjoeka PronkMary H Ward
Dec 25, 2010·Arhiv za higijenu rada i toksikologiju·Natalija MarinkovićAna Stavljenić Rukavina
Apr 15, 2014·Biological Trace Element Research·Montse MariJosé L Domingo
Feb 20, 2013·International Journal of Hygiene and Environmental Health·Montse MariJosé L Domingo
Oct 18, 2011·The Science of the Total Environment·M B ZuberoJ R Sáenz
Aug 12, 2009·Chemosphere·Hermann FrommeGabriele Bolte
Jan 24, 2009·Environment International·Marta SchuhmacherJosé L Domingo
Sep 5, 2013·The Science of the Total Environment·Hyokeun ParkYoon-Seok Chang
Sep 17, 2019·Critical Reviews in Toxicology·Laura CampoSilvia Fustinoni
Sep 27, 2019·International Journal of Environmental Research and Public Health·Montse Marquès, Jose L Domingo
Jul 11, 2018·Environmental Science and Pollution Research International·Montse MarquèsJosé L Domingo

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