Concentrations of serum total activin A and inhibin A in preterm and term labor patients: a cross-sectional study

Journal of the Society for Gynecologic Investigation
Michael P PlevyakHelayne M Silver

Abstract

To compare maternal serum levels of total activin A and inhibin A in preterm and term patients who are in labor or not in labor. A cross-sectional study compared activin A and inhibin A in the following groups of patients: preterm and in labor (n = 65), preterm and not in labor (n = 96), term and in labor (n = 65), and term and not in labor (n = 65). Preterm was defined as 23-34 weeks' gestation and term as 37-42 weeks' gestation. Labor was defined as regular contractions with progressive cervical change or an initial examination revealing cervical dilation of 1-3 cm with 50% effacement or more. Follistatin levels were analyzed in a subset of 12 patients from each group. Analytes were measured by two-site enzyme-linked immunosorbent assays. Activin A levels were higher in the preterm labor group (median 1.38 multiples of the median [MoM], interquartile range [IQR] 1.01 MoM) compared with the preterm nonlabor group (median 1.0 MoM, IQR 0.78 MoM, P <.05) and in the term labor group (median 1.37 MoM, IQR 1.74 MoM) compared with the term nonlabor group (median 1.0 MoM, IQR 0.87 MoM, P <.05). Inhibin A levels were higher in the preterm labor group (median 1.27 MoM, IQR 0.73 MoM) compared with the preterm nonlabor group (median 1.0 M...Continue Reading

Citations

Feb 2, 2008·Endocrinology·Pasquapina CiarmelaWylie Vale
May 15, 2013·Reproductive Biomedicine Online·E A M KuijperC B Lambalk
Dec 8, 2007·Clinics in Perinatology·John D Yeast, George Lu
Aug 30, 2005·Obstetrics and Gynecology Clinics of North America·John D Yeast, George Lu
May 10, 2012·The Journal of Obstetrics and Gynaecology Research·Jing GuoMinyue Dong
May 7, 2021·Science Translational Medicine·Ina A StelzerBrice Gaudillière

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