PMID: 15362493Sep 15, 2004Paper

Concentrations of signal transduction proteins exercise and insulin responses in rat extensor digitorum longus and soleus muscles

Molecular and Cellular Biochemistry
Philip J AthertonHenning Wackerhage

Abstract

Differences in the concentrations of signal transduction proteins often alter cellular function and phenotype, as is evident from numerous, heterozygous knockout mouse models for signal transduction proteins. Here, we measured signal transduction proteins involved in the adaptation to exercise and insulin signalling in fast rat extensor digitorum longus (EDL; 3% type I fibres) and the slow soleus muscles (84% type I fibres). The EDL and soleus were excised from four rats, the proteins extracted and subjected to Western blots for various signal transduction proteins. Our results show major differences in signal transduction protein concentrations between EDL and soleus. The EDL to soleus concentration ratios were: Calcineurin: 1.43 +/- 0.10; ERK1: 0.38 +/- 0.18; ERK2: 0.61 +/- 0.16; p38alpha, beta: 1.36 +/- 0.15; p38gamma/ERK6: 0.95 +/- 0.11; PKB/AKT: 1.44 +/- 0.08; p70S6k: 6.86 +/- 3.58; GSK3beta: 0.69 +/- 0.03; myostatin: 1.95 +/- 0.43; NF-kappaB: 0.32 +/- 0.10 (values >1 indicate higher expression in the EDL, and values < 1 indicate higher expression in the soleus). With the exception of p38gamma/ERK6, the concentration of each signal transduction protein was uniformly higher in one muscle than in the other in all four animal...Continue Reading

Citations

Oct 26, 2007·Experimental Biology and Medicine·Wan-Jung A TsaiGayle A Brazeau
Jul 23, 2009·American Journal of Physiology. Endocrinology and Metabolism·Karin StadlbauerClemens Fürnsinn
Feb 19, 2010·Animal Science Journal = Nihon Chikusan Gakkaihō·Susumu MuroyaTakahiro Yamaguchi
May 12, 2017·European Journal of Applied Physiology·Lewan ParkerItamar Levinger
Jul 6, 2010·European Journal of Applied Physiology·T van WesselR T Jaspers
Aug 16, 2019·General and Comparative Endocrinology·Takaoki SaneyasuHiroshi Kamisoyama

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