Concentrations of vanadium in urine and seminal plasma in relation to semen quality parameters, spermatozoa DNA damage and serum hormone levels

The Science of the Total Environment
Yi-Xin WangWen-Qing Lu

Abstract

Widespread human exposure to vanadium has been well documented. Vanadium exposure was reported to induce male reproductive toxicity in toxicological studies, yet human epidemiologic studies are lacking. Here we determined the associations between environmental exposure to vanadium and semen quality, spermatozoa DNA damage and serum reproductive hormones. Concentrations of vanadium in seminal plasma and repeated urine samples were determined among 764 men recruited from a reproductive medicine centre. Associations of vanadium concentrations with semen quality parameters (n = 764), DNA integrity measures (n = 404) and serum reproductive hormones (n = 381) were assessed by logistic or linear regression models with adjustment for potential confounders. Significant positive dose-response relationships were observed between vanadium concentrations in seminal plasma and tail length and serum estradiol, as well as odds ratios for a below-reference-value sperm concentration; whereas inverse relationships between seminal plasma vanadium with total testosterone (T) and free T (all p values for trends <0.05) were observed. These relationships were maintained after adjusting for seminal plasma concentrations of other elements (i.e., arsenic...Continue Reading

Citations

Mar 19, 2020·International Journal of Environmental Research and Public Health·Adam ProkopowiczLeon Kośmider
Feb 11, 2021·Biological Trace Element Research·Rubí Rodríguez-DíazRaquel Blanes-Zamora
Feb 20, 2021·Ecotoxicology and Environmental Safety·Shunli JiangQing Lu
Mar 28, 2021·Ecotoxicology and Environmental Safety·Aldo E CalogeroMargherita Ferrante

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