Concentrations of vitamin C, vitamin B12 and folic acid in patients treated with hemodialysis and on-line hemodiafiltration or hemofiltration

Scandinavian Journal of Urology and Nephrology
Ingela Fehrman-EkholmAnders Kallner

Abstract

Uncertainty has arisen as to whether vitamin supplements are needed by dialysis patients, in particular those treated by means of hemofiltration or hemodiafiltration using highly permeable (high-flux) filters. We therefore measured the concentrations of vitamin C, cobalamin (vitamin B12) and folic acid in conventional (low-flux) dialysis patients and in those receiving on-line treatment (hemofiltration or hemodiafiltration). Plasma (P-)ascorbate, serum (S-)cobalamin and S-folate concentrations were measured before and after a treatment session in 15 patients treated with low-flux hemodialysis and in 14 treated with on-line hemofiltration or hemodiafiltration. The patients' vitamin supplementations were also recorded. P-ascorbate concentrations were lowered by 51% and 53% in the hemodialysis and on-line groups, respectively after treatment and this reduction was significant (p<0.001). Concentrations below the reference values were found in 12/14 patients not receiving vitamin C supplementation. S-cobalamin did not decrease in the hemodialysis or on-line groups. S-folates did not change significantly in the hemodialysis or filtration groups. Patients without folacin supplementation had low values. P-ascorbate was reduced by both ...Continue Reading

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Citations

Feb 5, 2010·Kidney International·Peter J BlankestijnBernard Canaud
Jun 12, 2010·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Carolina Gracia-IguacelJuan J Carrero
Jul 19, 2013·Seminars in Dialysis·Catherine M ClaseRachel M Holden
Mar 13, 2012·Nephrology·Kunying ZhangLi Zuo
Nov 26, 2010·Hemodialysis International·Natalie CoveneyPeter G Kerr
Feb 8, 2014·Renal Failure·George KosmadakisDidier Aguilera
May 18, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Melissa SoohooKamyar Kalantar-Zadeh
Dec 13, 2017·Critical Care : the Official Journal of the Critical Care Forum·Anitra C CarrGeoff M Shaw
Nov 24, 2018·Critical Care : the Official Journal of the Critical Care Forum·Paul E Marik, Michael H Hooper
Oct 23, 2019·Journal of Translational Internal Medicine·Patrick M HonoreHerbert D Spapen
Feb 14, 2020·Annals of Intensive Care·Patrick M HonoreHeleen Oudemans-van Straaten
Aug 18, 2018·Critical Care : the Official Journal of the Critical Care Forum·Patrick M HonoreHerbert D Spapen
Jan 11, 2019·Critical Care : the Official Journal of the Critical Care Forum·Patrick M HonoreHerbert D Spapen
Nov 25, 2011·Hemodialysis International·Jennifer Cross, Andrew Davenport

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