Concept of Viral Inhibitors via NTCP

Seminars in Liver Disease
Kento FukanoTakaji Wakita

Abstract

Identification of sodium taurocholate cotransporting polypeptide (NTCP) as an entry receptor for hepatitis B and D viruses (HBV and HDV) has not only promoted our understanding of the mechanism underlying the viral entry process, but also provided cell culture models supporting viral infection. These models have greatly facilitated cell-based chemical screening for the discovery of entry inhibitors, and mode of action studies using such inhibitors have shown the advantages of NTCP as a drug target. Furthermore, in vitro chemical screening by application of high-throughput affinity-based technologies that target NTCP has identified a variety of unique small molecules that interfere with viral entry. This review summarizes this hot topic in the development of HBV/HDV entry inhibitors, with special focus on the use of NTCP as a drug target.

Citations

Mar 7, 2020·Current Opinion in HIV and AIDS·Mohube B MaepaPatrick Arbuthnot
Feb 16, 2020·Medicinal Research Reviews·Xingyue Ji, Zhuorong Li
Jun 21, 2020·Viruses·John M Taylor
Nov 12, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kira A A T LowjagaJoachim Geyer
Apr 13, 2021·Expert Opinion on Therapeutic Targets·Mohube Betty MaepaPatrick Arbuthnot
Jun 4, 2021·Frontiers in Molecular Biosciences·Gary GrosserJoachim Geyer
Jun 3, 2021·Pharmaceuticals·Georgia-Myrto PriftiGrigoris Zoidis
Jul 10, 2021·World Journal of Gastroenterology : WJG·Grazia A NiroMarilena Durazzo

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