PMID: 2093643Jan 1, 1990Paper

Concepts and usefulness of pharmacokinetic-pharmacodynamic modelling

Fundamental & Clinical Pharmacology
N H Holford

Abstract

The combined application of pharmacokinetic and pharmacodynamic models to concentration and effect observations can be used to predict the consequences of alternative dosing strategies. Efficient experimental design is intimately related to the models that may be employed for data analysis. This is especially important in phase I studies which provide the basis for decisions on future clinical trials.

References

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Citations

Jan 13, 2006·Journal of Pharmacokinetics and Pharmacodynamics·Chantal Csajka, Davide Verotta
Jan 12, 1999·British Journal of Pharmacology·O E Della PaschoaM Danhof
Aug 1, 1992·Alcoholism, Clinical and Experimental Research·R M SwiftN Kackley
Oct 15, 2010·Journal of Clinical Pharmacology·Julie A StoneDennis M Grasela
Mar 24, 1993·Biochemical Pharmacology·K BrøsenS Loft
Dec 30, 1998·Pharmacology & Toxicology·B B RasmussenK Brøsen
Jul 1, 1996·The Journal of Pharmacy and Pharmacology·K U LeoT G Brewer
Jan 1, 1993·European Journal of Clinical Pharmacology·J Le HouezecN L Benowitz
Jun 19, 2016·BMJ Supportive & Palliative Care·Patrick D HoekJeroen G J Hasselaar

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