Concepts Collide: Genomic, Immune, and Microbial Influences on the Tumor Microenvironment and Response to Cancer Therapy

Frontiers in Immunology
Miles C AndrewsJennifer A Wargo

Abstract

Cancer research has seen unprecedented advances over the past several years, with tremendous insights gained into mechanisms of response and resistance to cancer therapy. Central to this has been our understanding of crosstalk between the tumor and the microenvironment, with the recognition that complex interactions exist between tumor cells, stromal cells, overall host immunity, and the environment surrounding the host. This is perhaps best exemplified in cancer immunotherapy, where numerous studies across cancer types have illuminated our understanding of the genomic and immune factors that shape responses to therapy. In addition to their individual contributions, it is now clear that there is a complex interplay between genomic/epigenomic alterations and tumor immune responses that impact cellular plasticity and therapeutic responses. In addition to this, it is also now apparent that significant heterogeneity exists within tumors-both at the level of genomic mutations as well as tumor immune responses-thus contributing to heterogeneous clinical responses. Beyond the tumor microenvironment, overall host immunity plays a major role in mediating clinical responses. The gut microbiome plays a central role, with recent evidence r...Continue Reading

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Citations

Oct 19, 2019·Oncology Nursing Forum·Diane Von AhMary E Cooley
Mar 11, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Richard K YangPaul M Sondel
Mar 20, 2021·Cancer Chemotherapy and Pharmacology·Eneida Turiján-EspinozaDiana Patricia Portales-Pérez
Mar 24, 2021·Journal of Clinical Pathology·Kate WilkinsonCheok Soon Lee
Aug 28, 2021·Microorganisms·Tereza VyhnalovaPetra Borilova Linhartova

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Methods Mentioned

BETA
biopsy
biopsies
whole genome shotgun sequencing

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