Concepts for developing a collaborative in silico model of the acute inflammatory response using agent-based modeling

Journal of Critical Care
Gary C An

Abstract

The complexity of the acute inflammatory response (AIR) is, by now, generally recognized. The primary manifestation of this property has been the difficulty in translating the information derived from reductionist, basic science research into effective clinical treatment regimens for sepsis. However, the recognition of the "complexity" of the AIR is not without its pitfalls. Despite its limitations, reductionism remains the primary means of obtaining scientific information. Furthermore, a functional shortcoming of use of the term complex has been to make it equivalent to "essentially unsolvable." Therefore, a mechanism is needed to integrate the apparatus of reductionist analysis into a complex synthetic methodology that overcomes the current limitations of both. Toward this end, I propose a structure for a class of collaborative, community-wide in silico models that use the framework of agent-based modeling. Agent-based modeling is a type of mathematical modeling that focuses on the behaviors of the components of complex systems and is well suited for translating the results of basic science experiments. I will also introduce a preliminary version of a syntactical "grammar" that can potentially be used to facilitate the transf...Continue Reading

References

Oct 1, 1996·The Journal of Trauma·T G Buchman
Aug 2, 2000·Critical Care Medicine·A J Seely, N V Christou
Jul 21, 2004·Bioinformatics·S A RacunasN V Fedoroff
Aug 17, 2004·Bioinformatics·J P MassarJeff Shrager
Aug 24, 2004·Journal of Theoretical Biology·Rukmini KumarCarson C Chow
Sep 24, 2004·Current Opinion in Critical Care·Yoram VodovotzGary An
Oct 16, 2004·Critical Care Medicine·Gilles ClermontCarson Chow
Oct 16, 2004·Critical Care Medicine·John C Marshall
Oct 16, 2004·Critical Care Medicine·Timothy G Buchman
Jan 13, 2005·Critical Care Medicine·Gary An

❮ Previous
Next ❯

Citations

Apr 25, 2012·Immunologic Research·Vipin NarangAlexandre Gouaillard
Jan 11, 2008·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Susan L Bratton, Brahm Goldstein
Jan 21, 2011·Theoretical Biology & Medical Modelling·Virginia A FolcikClay B Marsh
Apr 26, 2008·PLoS Computational Biology·Yoram VodovotzGary An
Jan 16, 2015·Journal of the Royal Society, Interface·Kieran AldenJon Timmis
May 1, 2015·Science Translational Medicine·David BrownYoram Vodovotz
Oct 1, 2007·Drug Discovery Today. Disease Models·Silvia Daun, Gilles Clermont
Sep 14, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Gary AnYoram Vodovotz
Jan 30, 2008·Birth Defects Research. Part C, Embryo Today : Reviews·Bryan C ThorneShayn M Peirce
Feb 1, 2009·Clinical and Translational Science·P T FoteinouI P Androulakis
Jan 20, 2010·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Gary C An
May 23, 2009·Molecular BioSystems·Craig E WheelockSusumu Goto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.