Conceptual framework for the definition of preclinical and prodromal frontotemporal dementia.

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
A BenussiB Borroni

Abstract

The presymptomatic stages of frontotemporal dementia (FTD) are still poorly defined and encompass a long accrual of progressive biological (preclinical) and then clinical (prodromal) changes, antedating the onset of dementia. The heterogeneity of clinical presentations and the different neuropathological phenotypes have prevented a prior clear description of either preclinical or prodromal FTD. Recent advances in therapeutic approaches, at least in monogenic disease, demand a proper definition of these predementia stages. It has become clear that a consensus lexicon is needed to comprehensively describe the stages that anticipate dementia. The goal of the present work is to review existing literature on the preclinical and prodromal phases of FTD, providing recommendations to address the unmet questions, therefore laying out a strategy for operationalizing and better characterizing these presymptomatic disease stages.

References

Apr 6, 1999·Archives of Neurology·R C PetersenE Kokmen
Dec 26, 2001·Archives of Neurology·R C PetersenB Winblad
Oct 9, 2002·Neurology·Catherine Lomen-HoerthBruce Miller
Dec 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Eric M ReimanJohn Hardy
Feb 18, 2004·Archives of Neurology·Román AlbercaMarsel Mesulam
Mar 9, 2004·Journal of Alzheimer's Disease : JAD·Alexandre de MendonçaCarlos Garcia
Jan 18, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·J C JanssenM N Rossor
Jul 22, 2005·Brain : a Journal of Neurology·Andrew KerteszDavid G Munoz
Feb 14, 2006·Annals of Neurology·William JagustMary Haan
Apr 25, 2006·Lancet·Serge GauthierUNKNOWN International Psychogeriatric Association Expert Conference on mild cognitive impairment
Oct 24, 2007·Neurobiology of Aging·Brendan J KelleyRonald C Petersen
Dec 11, 2007·Brain : a Journal of Neurology·Salvatore SpinaBernardino Ghetti
Feb 5, 2008·Brain : a Journal of Neurology·Isabelle Le BerUNKNOWN French research network on FTD/FTD-MND
Apr 2, 2008·The Journal of Cell Biology·Philip Van DammeWim Robberecht
Jul 24, 2008·Nature Clinical Practice. Neurology·Jonathan D RohrerNick C Fox
Oct 3, 2008·Brain : a Journal of Neurology·David S KnopmanNathaniel Mercaldo
May 27, 2009·Neuropsychologia·Yaakov Stern
Jan 20, 2010·Lancet Neurology·Clifford R JackJohn Q Trojanowski
Feb 16, 2010·Nature Genetics·Vivianna M Van DeerlinVirginia M-Y Lee
Jul 14, 2010·Psychological Medicine·D J SteinK S Kendler
Feb 18, 2011·Neurology·M L Gorno-TempiniM Grossman
Jul 15, 2011·Neurology·H SeelaarJ C van Swieten
Aug 4, 2011·Brain : a Journal of Neurology·Katya RascovskyBruce L Miller
Nov 24, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Ariane ChoumertStéphane Thobois
Dec 2, 2011·Neurobiology of Aging·Barbara BorroniMarco Bozzali
Jun 27, 2012·Nature Reviews. Neurology·Rosa RademakersIan R Mackenzie
Feb 16, 2013·Brain : a Journal of Neurology·Suzanne LesageUNKNOWN French Parkinson’s Disease Genetics Study Group
Mar 5, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Edward D HueyRichard Mayeux
Apr 24, 2013·Nature Reviews. Neurology·Barbara Borroni, Alessandro Padovani
May 21, 2013·Lancet Neurology·Maria Grazia Spillantini, Michel Goedert
Dec 7, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Marc Suárez-CalvetAlberto Lleó
Jan 5, 2014·Acta Neuropathologica·Marka van BlitterswijkRosa Rademakers

❮ Previous
Next ❯

Citations

Nov 17, 2021·Alzheimer's Research & Therapy·Alberto BenussiBarbara Borroni

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Alzheimer's Disease and Other Dementias
Bradley J HallamHoward Feldman
The New Zealand Medical Journal
Sayed Mahdi MarashiZeynab Nasri-Nasabadi
© 2022 Meta ULC. All rights reserved