CONCERN: Does ovary need D-chiro-inositol?

Journal of Ovarian Research
Rosalbino Isabella, E Raffone

Abstract

Polycystic Ovary Syndrome (PCOS) is a multifactorial pathology that affects 10% of the women in reproductive age being the main cause of infertility due to menstrual dysfunction. Since 1980, it is known that PCOS is associated with insulin resistance (IR). The recognition of this association has prompted extensive investigation on the relationship between insulin and gonadal function, and has turned insulin sensitizer agent as the main therapeutic choice. In particular two different polyalcohol myo-inositol and D-chiro-inositol have been shown to improve insulin resistance, hyperandrogenism and to induce ovulation in PCOS women. In particular, while data on myo-inositol and restored ovulation were consistent, data on D-chiro-inositol were not . Recently, a comparative study, proposed a D-chiro-inositol paradox in the ovary of PCOS patients hypothesizing that only myo-inositol has a specific ovarian action. In the present study we aim to further study the role played by D-chiro-inositol at ovarian level. A total of 54 women, aged <40 years and diagnosed with PCOS were enrolled in this study. Patients with insulin resistance and/or hyperglycaemia were excluded from the study. Patients were randomly divided into 5 groups (n=10-12)...Continue Reading

References

Jan 1, 1980·The Journal of Clinical Endocrinology and Metabolism·G A BurghenA E Kitabchi
Jan 1, 1996·Diabetes Care·J Larner, J W Craig
Jan 29, 1999·Endocrinology and Metabolism Clinics of North America·A E Taylor
Apr 29, 1999·The New England Journal of Medicine·J E NestlerG Allan
Jun 3, 1999·Endocrinology and Metabolism Clinics of North America·D A Ehrmann
Mar 20, 2002·International Journal of Experimental Diabetes Research·Joseph Larner
Dec 23, 2003·Human Reproduction·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group
Jan 9, 2004·Fertility and Sterility·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group
Jan 13, 2004·The Journal of Clinical Endocrinology and Metabolism·Jean-Patrice BaillargeonJohn E Nestler
May 11, 2006·Archives of Gynecology and Obstetrics·I MatalliotakisD Panidis
Apr 12, 2007·Hormone Research·Katerina HarwoodJoan DiMartino-Nardi
Jun 15, 2007·Molecular Human Reproduction·Xiang MaJia-Yin Liu
Jun 15, 2007·Fertility and Sterility·Jean-Patrice Baillargeon, André Carpentier
Oct 24, 2007·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Enrico PapaleoAugusto Ferrari
Oct 6, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·E PapaleoT T Chiu
Dec 29, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Catherine G BaptisteJean-Patrice Baillargeon
Mar 13, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Emanuela RaffoneVincenzo Benedetto
Jun 7, 2011·Fertility and Sterility·Gianfranco CarlomagnoScott Roseff

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Citations

Jun 4, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Arturo BevilacquaZdravko A Kamenov
Jun 6, 2014·Expert Review of Clinical Pharmacology·Vittorio Unfer, Giuseppina Porcaro
Mar 2, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Cristiana PaulDavid M Brady
Jul 22, 2014·Journal of Clinical Pharmacology·Simona DinicolaMariano Bizzarri
Apr 28, 2016·Best Practice & Research. Clinical Obstetrics & Gynaecology·Arturo Bevilacqua, Mariano Bizzarri
May 5, 2016·Medical Hypotheses·Mariano BizzarriArturo Bevilacqua
Jun 29, 2016·Expert Opinion on Drug Metabolism & Toxicology·Mariano BizzarriArturo Bevilacqua
Sep 1, 2016·International Journal of Endocrinology·Antonio Simone LaganàOnofrio Triolo
Aug 27, 2016·Expert Opinion on Drug Metabolism & Toxicology·Vittorio UnferGiovanni Monastra
Sep 22, 2016·International Journal of Endocrinology·Salvatore Giovanni VitaleMassimo Buscema
Sep 7, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ewa M MilewskaAlessandro D Genazzani
Oct 9, 2016·Reproductive Biomedicine Online·Alessandro D Genazzani
Oct 12, 2016·International Journal of Endocrinology·Rosa LaurettaMarialuisa Appetecchia
Nov 1, 2016·International Journal of Endocrinology·Deepika Garg, Reshef Tal
Nov 30, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Giovanni MonastraMariano Bizzarri
Feb 7, 2014·Reproductive Sciences·Vittorio UnferJean-Patrice Baillargeon
Jul 29, 2017·The Cochrane Database of Systematic Reviews·Marian G ShowellRoger J Hart
Jan 9, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Antoaneta GatevaZdravko Kamenov
Jul 7, 2018·Journal of Ovarian Research·Rosalbino Isabella, Emanuela Raffone
Dec 21, 2018·The Cochrane Database of Systematic Reviews·Marian G ShowellCindy Farquhar
May 12, 2018·Journal of Ovarian Research·Mario Montanino OlivaVittorio Unfer
Nov 16, 2016·International Journal of Endocrinology·Vittorio UnferFabio Facchinetti
Mar 19, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Nicolas MendozaJuristo Fonolla
Nov 25, 2018·Journal of Ovarian Research·Rosalbino Isabella, Emanuela Raffone
Nov 23, 2019·International Journal of Molecular Sciences·Anna WojciechowskaJoanna Wojtkiewicz
Jan 1, 2019·International Journal of Endocrinology·Arturo Bevilacqua, Mariano Bizzarri
Dec 19, 2020·International Journal of Molecular Sciences·Andrea CignarellaCarla Scaroni

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Methods Mentioned

BETA
pregnancy test

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