PMID: 9434947Jan 22, 1998Paper

Concerted evolution of members of the multisequence family chAB4 located on various nonhomologous chromosomes

Mammalian Genome : Official Journal of the International Mammalian Genome Society
G AssumG Wöhr

Abstract

During the last years it became obvious that a lot of families of long-range repetitive DNA elements are located within the genomes of mammals. The principles underlying the evolution of such families, therefore, may have a greater impact than anticipated on the evolution of the mammalian genome as a whole. One of these families, called chAB4, is represented with about 50 copies within the human and the chimpanzee genomes and with only a few copies in the genomes of gorilla, orang-utan, and gibbon. Members of chAB4 are located on 10 different human chromosomes. FISH of chAB4-specific probes to chromosome preparations of the great apes showed that chAB4 is located, with only one exception, at orthologous places in the human and the chimpanzee genome. About half the copies in the human genome belong to two species-specific subfamilies that evolved after the divergence of the human and the chimpanzee lineages. The analysis of chAB4-specific PCR-products derived from DNA of rodent/human cell hybrids showed that members of the two human-specific subfamilies can be found on 9 of the 10 chAB4-carrying chromosomes. Taken together, these results demonstrate that the members of DNA sequence families can evolve as a unit despite their loc...Continue Reading

References

Nov 20, 1992·Journal of Molecular Biology·K F CooperC Tyler-Smith
Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D L GradyR K Moyzis
Oct 1, 1991·Genomics·G AssumG Wöhr
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J S Waye, H F Willard
Jan 1, 1986·Annual Review of Genetics·N Maeda, O Smithies
Jan 1, 1987·Journal of Molecular Evolution·C G Sibley, J E Ahlquist
Jan 1, 1983·Cold Spring Harbor Symposia on Quantitative Biology·A M Weiner, R A Denison
Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M KrystalN Arnheim
Mar 19, 1982·Science·J J Yunis, O Prakash
Jun 1, 1995·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·W SchemppA C Chandley
May 1, 1994·Genomics·G AssumG Wöhr
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·J C EikenboomP H Reitsma
May 1, 1993·Genomics·H L DrwingaR A Mulivor
May 1, 1996·Human Molecular Genetics·J C van DeutekomR R Frants

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.