PMID: 375002Jan 16, 1979Paper

Concerted repression of the synthesis of the arginine biosynthetic enzymes by aminoacids: a comparison between the regulatory mechanisms controlling aminoacid biosyntheses in bacteria and in yeast

Molecular & General Genetics : MGG
F Messenguy

Abstract

It has been shown that in bacteria, besides specific regulatory mechanisms, the synthesis of aminoacid biosynthetic enzymes is also controlled by the endogenous aminoacid pool. The latter regulates the intracellular level of ppGpp, a positive effector of RNA messenger transcription. A similar regulatory control exists in yeast but does not appear to involve the same general effector. This was established by the observation that derepression of the enzymes belonging to several aminoacid biosynthetic pathways follows aminoacid starvation or tRNA discharging. We now report the repression of the arginine pathway by the total aminoacid pool. New mutations affecting the repressibility of the arginine enzymes as well as enzymes belonging to other aminoacid biosyntheses, when cells are grown in the presence of an excess of aminoacids, were identified.

References

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Citations

Nov 1, 1990·Molecular & General Genetics : MGG·F Messenguy, B Scherens
Jan 1, 1980·Molecular & General Genetics : MGG·A Mountain, S Baumberg
Jan 1, 1987·Current Genetics·M K Winston, J K Bhattacharjee
Jan 1, 1985·Current Genetics·L A UrrestarazuJ K Bhattacharjee
Apr 1, 1982·Genetical Research·I B Barthelmess
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M D PennH Greer
Jan 1, 1986·CRC Critical Reviews in Biochemistry·A G Hinnebusch
Jan 1, 1985·Critical Reviews in Microbiology·J K Bhattacharjee
Jan 1, 1981·Zeitschrift für allgemeine Mikrobiologie·R Bode, D Birnbaum
Oct 1, 1982·Molecular and Cellular Biology·S J SilvermanG R Fink
Sep 1, 1986·Microbiological Reviews·R CuninV Stalon
Jul 1, 1981·Molecular and Cellular Biology·P NiederbergerR Hütter

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