Concise prediction models of anticancer efficacy of 8 drugs using expression data from 12 selected genes

International Journal of Cancer. Journal International Du Cancer
Tomotaka TanakaMasahiko Nishiyama

Abstract

We developed concise, accurate prediction models of the in vitro activity for 8 anticancer drugs (5-FU, CDDP, MMC, DOX, CPT-11, SN-38, TXL and TXT), along with individual clinical responses to 5-FU using expression data of 12 genes. We first performed cDNA microarray analysis and MTT assay of 19 human cancer cell lines to sort out genes which were correlative in expression levels with cytotoxicities of the 8 drugs; we selected 13 genes with proven functional significance to drug sensitivity from a huge number of potent prediction marker genes. The correlation significance of each was confirmed using expression data quantified by real-time RT-PCR, and finally 12 genes (ABCB1, ABCG2, CYP2C8, CYP3A4, DPYD, GSTP1, MGMT, NQO1, POR, TOP2A, TUBB and TYMS) were selected as more reliable predictors of drug response. Using multiple regression analysis, we fixed 8 prediction formulae which embraced the variable expressions of the 12 genes and arranged them in order, to predict the efficacy of the drugs by referring to the value of Akaike's information criterion for each sample. These formulae appeared to accurately predict the in vitro efficacy of the drugs. For the first clinical application model, we fixed prediction formulae for indivi...Continue Reading

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Citations

Dec 2, 2005·Langenbeck's Archives of Surgery·Hiroshi ShimadaShinji Togo
Mar 26, 2011·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Hiroshi SanoMasahiko Nishiyama
Mar 22, 2006·Oncogene·C Rodriguez-Antona, M Ingelman-Sundberg
Mar 31, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jae Yong ChoJu-Seog Lee
Mar 25, 2011·BMC Medical Genomics·Shih-Yi ChaoWoan-Shan Chang
Oct 27, 2012·Experimental Lung Research·Ahmed El Sayed MohammedMasahiko Nishiyama
Jan 22, 2009·Advanced Drug Delivery Reviews·Masahiko Nishiyama, Hidetaka Eguchi
Jan 10, 2009·Advanced Drug Delivery Reviews·Masahiko Nishiyama, Hidetaka Eguchi
Oct 1, 2008·Cancer Letters·Shoichi FumotoMasahiko Nishiyama
Sep 19, 2015·Computational and Structural Biotechnology Journal·Xiandong LinBin Zhang
Feb 11, 2005·Current Opinion in Chemical Biology·Rebecca A Butcher, Stuart L Schreiber
Jul 29, 2016·World Journal of Gastroenterology : WJG·Marwa MatboliOmar Abdel-Rahman
Feb 24, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Tian-Lu WangYu-Xia Zhao
Oct 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jennifer D WuStephen R Plymate
Mar 21, 2006·Molecular Cancer Therapeutics·Masaaki KomatsuMasahiko Nishiyama

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