Concise Review: Biomimetic Functionalization of Biomaterials to Stimulate the Endogenous Healing Process of Cartilage and Bone Tissue

Stem Cells Translational Medicine
Francesca TaraballiEnnio Tasciotti

Abstract

Musculoskeletal reconstruction is an ongoing challenge for surgeons as it is required for one out of five patients undergoing surgery. In the past three decades, through the close collaboration between clinicians and basic scientists, several regenerative strategies have been proposed. These have emerged from interdisciplinary approaches that bridge tissue engineering with material science, physiology, and cell biology. The paradigm behind tissue engineering is to achieve regeneration and functional recovery using stem cells, bioactive molecules, or supporting materials. Although plenty of preclinical solutions for bone and cartilage have been presented, only a few platforms have been able to move from the bench to the bedside. In this review, we highlight the limitations of musculoskeletal regeneration and summarize the most relevant acellular tissue engineering approaches. We focus on the strategies that could be most effectively translate in clinical practice and reflect on contemporary and cutting-edge regenerative strategies in surgery. Stem Cells Translational Medicine 2017;6:2186-2196.

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Citations

Jul 12, 2018·Advanced Healthcare Materials·Francesca TaraballiEnnio Tasciotti
Aug 18, 2020·Organogenesis·Le-Yi ZhangXiao-Yi Chen
Dec 15, 2020·Tissue Engineering. Part B, Reviews·Anna TrengoveAndrea J O'Connor
Feb 13, 2021·Small·Fatemeh OroojalianMohammad-Ali Shahbazi
Jan 8, 2021·Annals of Biomedical Engineering·Anamarija RoginaHrvoje Ivanković
Mar 30, 2019·Biochemical and Biophysical Research Communications·Naoyo KajitaniKen-Ichi Matsumoto
Apr 7, 2021·Acta Biomaterialia·Molly KlimakFarshid Guilak

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Methods Mentioned

BETA
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