Concise review: current trends on applications of stem cells in diabetic nephropathy.

Cell Death & Disease
Dongwei LiuZhangsuo Liu

Abstract

Diabetic nephropathy, with high prevalence, is the main cause of renal failure in diabetic patients. The strategies for treating DN are limited with not only high cost but an unsatisfied effect. Therefore, the effective treatment of DN needs to be explored urgently. In recent years, due to their self-renewal ability and multi-directional differentiation potential, stem cells have exerted therapeutic effects in many diseases, such as graft-versus-host disease, autoimmune diseases, pancreatic diseases, and even acute kidney injury. With the development of stem cell technology, stem cell-based regenerative medicine has been tried to be applied to the treatment of DN. Related stem cells include embryonic stem cells, induced pluripotent stem cells, mesenchymal cells, and endothelial progenitor cells. Undoubtedly, stem cell transplantation has achieved certain results in the treatment of DN animal models. However, stem cell therapy still remains certain thorny issues during treatment. For instance, poor engraftment and limited differentiation of stem cells caused by the diabetic microenvironment, differentiation into unwanted cell lineages, and malignant transformation or genetic aberrations of stem cells. At present, various researc...Continue Reading

References

Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G R Martin
Nov 6, 1998·Science·J A ThomsonJ M Jones
Apr 2, 1999·Science·M F PittengerD R Marshak
Jan 6, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·P MaisonneuveP Boyle
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·M SchuldinerN Benvenisty
Sep 22, 2001·The New England Journal of Medicine·T H Hostetter
Aug 15, 2002·Cell·Hynek WichterleThomas M Jessell
Jun 12, 2003·Annals of the New York Academy of Sciences·George Q Daley
Oct 9, 2003·Kidney International·Ferdinand H BahlmannDanilo Fliser
Dec 31, 2003·Methods in Enzymology·Gabriela KaniaAnna M Wobus
Sep 11, 2004·Biochemical and Biophysical Research Communications·Norman EndeAlluru S Reddi
Apr 29, 2005·Journal of the American Society of Nephrology : JASN·Fiona Y ChowGregory H Tesch
May 3, 2005·Journal of the American College of Cardiology·Gian Paolo FadiniAngelo Avogaro
Aug 18, 2005·American Journal of Physiology. Renal Physiology·Makoto YamamotoKatsunori Sasaki
Sep 6, 2005·Biochemical and Biophysical Research Communications·Takahiko KobayashiYoshio Terada
Oct 21, 2005·International Journal of Clinical Practice·C J BaileyUNKNOWN Global Partnership for Effective Diabetes Management
Nov 4, 2005·Journal of the American Society of Nephrology : JASN·Doyeob Kim, Gregory R Dressler
Nov 24, 2005·Hematology·William Tse, Mary J Laughlin
Mar 1, 2006·Diabetes Care·Gian Paolo FadiniAngelo Avogaro
Nov 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ryang Hwa LeeDarwin J Prockop
Jan 11, 2007·American Journal of Physiology. Renal Physiology·Florian TögelChristof Westenfelder
Jan 31, 2007·Journal of Translational Medicine·Neil H RiordanThomas E Ichim
Oct 19, 2007·Journal of the American Society of Nephrology : JASN·Barbara ImbertiGiuseppe Remuzzi
Nov 22, 2007·Science·Junying YuJames A Thomson
Feb 6, 2008·Atherosclerosis·Gian Paolo FadiniAngelo Avogaro
May 21, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Fernando E EzquerPaulette A Conget
Jun 14, 2008·Virchows Archiv : an International Journal of Pathology·Yoko Abe-YoshioShigeru Kohno
Jun 21, 2008·Stem Cells and Development·Florian TögelChristof Westenfelder
Sep 23, 2008·The Journal of Urology·Yuanyuan ZhangAnthony Atala
Dec 4, 2008·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Emile R MohlerRobert L Wilensky
Feb 25, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·H MakinoY Yoshimasa
May 28, 2009·Journal of the American Society of Nephrology : JASN·Hiroki FujitaTakamune Takahashi
Oct 14, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Fernando EzquerPaulette Conget
Nov 28, 2009·Current Stem Cell Research & Therapy·Alexander M BaileyAdam J Katz
Feb 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Bao-Yang HuSu-Chun Zhang
Jun 23, 2010·Human Gene Therapy·Pierre Charbord
Jul 3, 2010·Stem Cells·Jakub TolarBruce R Blazar
Aug 20, 2010·Cardiovascular Therapeutics·Ahmed A Elmarakby, Jennifer C Sullivan

❮ Previous
Next ❯

Methods Mentioned

BETA
gene modification

Clinical Trials Mentioned

NCT02585622

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
Guang Yang, Qing-li Cheng
Clujul medical : revistă de medicină şi farmacie
Mihai GirlovanuCarmen Mihaela Mihu
Nature Reviews. Urology
Kehkooi KeePaul J Turek
© 2021 Meta ULC. All rights reserved