Concise Review: Prostate Cancer Stem Cells: Current Understanding.

Stem Cells
Sergej SkvortsovAnna Dubrovska

Abstract

Prostate cancer (PCa) is heterogeneous, harboring phenotypically diverse cancer cell types. PCa cell heterogeneity is caused by genomic instability that leads to the clonal competition and evolution of the cancer genome and by epigenetic mechanisms that result in subclonal cellular differentiation. The process of tumor cell differentiation is initiated from a population of prostate cancer stem cells (PCSCs) that possess many phenotypic and functional properties of normal stem cells. Since the initial reports on PCSCs in 2005, there has been much effort to elucidate their biological properties, including unique metabolic characteristics. In this Review, we discuss the current methods for PCSC enrichment and analysis, the hallmarks of PCSC metabolism, and the role of PCSCs in tumor progression. Stem Cells 2018;36:1457-1474.

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Citations

Apr 11, 2019·International Journal of Cancer. Journal International Du Cancer·Ielizaveta GorodetskaAnna Dubrovska
Apr 17, 2019·Journal of Lipid Research·Shai White-GilbertsonChristina Voelkel-Johnson
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Dec 13, 2019·Oxidative Medicine and Cellular Longevity·Tiziana Tataranni, Claudia Piccoli
Oct 9, 2020·Signal Transduction and Targeted Therapy·Siyuan QinWeifeng He
Jan 7, 2021·Cancers·Uğur KahyaAnna Dubrovska
Aug 14, 2020·Journal of Natural Products·Roberta BortolozziGiampietro Viola
Mar 25, 2021·Cancer Management and Research·Weizhu ZhaoLigang Xing
Mar 26, 2021·Frontiers in Cell and Developmental Biology·Wen Jess LiDean G Tang
Mar 9, 2021·Signal Transduction and Targeted Therapy·Chaoyue SuLiwu Fu
Nov 12, 2018·Biochemical Pharmacology·François M ValletteDominique Heymann
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Jun 5, 2021·Mutation Research. Reviews in Mutation Research·Mohammad Mahmoudi GomariParastoo Tarighi
Dec 9, 2020·Seminars in Cancer Biology·Claudia PeitzschAnna Dubrovska

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