Concise Review: Regulatory Influence of Sleep and Epigenetics on Adult Hippocampal Neurogenesis and Cognitive and Emotional Function

Stem Cells
Katherine G AkersMasanori Sakaguchi

Abstract

Neural stem and progenitor cells continue to generate new neurons in particular regions of the brain during adulthood. One of these neurogenic regions is the dentate gyrus (DG) of the hippocampus, which plays an important role in cognition and emotion. By exploiting this innate neuronal regeneration mechanism in the DG, new technologies have the potential to promote resistance to or recovery from brain dysfunction or degeneration. However, a deeper understanding of how adult DG neurogenesis is regulated by factors such as sleep and epigenetic modifications of gene expression could lead to further breakthroughs in the clinical application of neural stem and progenitor cells. In this review, we discuss the functions of adult-born DG neurons, describe the epigenetic regulation of adult DG neurogenesis, identify overlaps in how sleep and epigenetic modifications impact adult DG neurogenesis and memory consolidation, and suggest ways of using sleep or epigenetic interventions as therapies for neurodegenerative and psychiatric disorders. By knitting together separate strands of the literature, we hope to trigger new insights into how the functions of adult-generated neurons are directed by interactions between sleep-related neural pr...Continue Reading

References

Jul 29, 1994·Science·M A Wilson, B L McNaughton
Nov 11, 1998·Nature Medicine·P S ErikssonF H Gage
Feb 8, 2002·Neuron·György Buzsáki
Jan 20, 2006·Hippocampus·Benedetta LeunerTracey J Shors
May 30, 2006·Nature Neuroscience·James B AimoneFred H Gage
May 22, 2007·Nature Reviews. Neuroscience·Elizabeth Gould
Feb 22, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Anka D MuellerRalph E Mistlberger
Mar 11, 2008·Trends in Neurosciences·Jerome M Siegel
Sep 15, 2009·Nature Neuroscience·Gabrielle GirardeauMichaël B Zugaro
Jan 5, 2010·Nature Reviews. Neuroscience·Susanne Diekelmann, Jan Born
Mar 15, 2011·The European Journal of Neuroscience·Gerd Kempermann
May 31, 2011·Neurobiology of Aging·Stanley E Lazic
Aug 19, 2011·The EMBO Journal·Jose P Lopez-AtalayaAngel Barco
Sep 13, 2011·Nature Methods·Kunal K GhoshMark J Schnitzer
Oct 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maithe Arruda-CarvalhoPaul W Frankland
Apr 25, 2012·Frontiers in Neurology·Michele FerraraLino Nobili
Aug 1, 2012·Current Topics in Behavioral Neurosciences·Carmen VivarHenriette van Praag
Oct 27, 2012·Neurologic Clinics·Andrew D Krystal
Feb 26, 2013·Trends in Cognitive Sciences·Delphine Oudiette, Ken A Paller
Jun 12, 2013·Cell·Kirsty L SpaldingJonas Frisén
Jun 28, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Snehajyoti ChatterjeeAnne-Laurence Boutillier
Jul 12, 2013·Psychological Medicine·B KleimB Rasch
Sep 14, 2013·Current Biology : CB·Ted AbelMatthew P Walker
Sep 21, 2013·Learning & Memory·Toni-Moi Prince, Ted Abel
Nov 13, 2013·Current Topics in Behavioral Neurosciences·Anka D MuellerRalph E Mistlberger
Jan 11, 2014·Annals of Medicine·Irene GriesauerDaniela D Pollak
Sep 19, 2014·Neuron·Nancy J KopellMark A Kramer
Sep 23, 2014·Current Opinion in Neurobiology·Bradley R Miller, René Hen
May 3, 2015·Cold Spring Harbor Perspectives in Biology·Irmgard Amrein
May 23, 2015·Nature Reviews. Drug Discovery·Moshe Szyf
Jun 13, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Antoine Besnard, Amar Sahay
Aug 5, 2015·Cold Spring Harbor Perspectives in Biology·Melody V WuRené Hen

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Citations

Dec 12, 2018·Neural Regeneration Research·Iyo KoyanagiMasanori Sakaguchi
Jun 25, 2019·European Psychiatry : the Journal of the Association of European Psychiatrists·Xue GaoTong Wang
Jul 2, 2020·Journal of Clinical Medicine·Gianina Luca, Lola Peris
Aug 21, 2020·Integrative Medicine Research·Sun-Hye ChoiSeung-Yeol Nah
Nov 28, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Shogo SatoRicardo Orozco-Solis
Nov 12, 2021·Human Molecular Genetics·Ancha BaranovaFuquan Zhang

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