Concise Review: TLR Pathway-miRNA Interplay in Mesenchymal Stromal Cells: Regulatory Roles and Therapeutic Directions

Stem Cells
Jahangir AbdiArmand Keating

Abstract

Mesenchymal stromal cells (MSCs) deploy Toll-like receptors (TLRs) to respond to exogenous and endogenous signals. Activation of TLR pathways in MSCs alters their inflammatory profile and immunomodulatory effects on cells from both the innate and adaptive immune systems. Micro-RNAs (miRNAs), whose expression is modulated by TLR activation, can regulate inflammatory responses by targeting components of the TLR signaling pathways either in MSCs or in the cells with which they interact. Here, we review how the miRNA-TLR pathway axis can regulate the immunomodulatory functions of MSCs, including their interactions with monocytes/macrophages and natural killer cells, and discuss the therapeutic implications for MSC-based therapies. Stem Cells 2018;36:1655-1662.

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Mar 13, 2020·EMBO Reports·Saira MunirKarin Scharffetter-Kochanek
Sep 19, 2019·Stem Cells International·Fabiana Evaristo-MendonçaPedro Moreno Pimentel-Coelho
Feb 12, 2020·Journal of Clinical Medicine·Gonzalo José Jimenez-PuertaPatricia Gálvez-Martín
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Aug 28, 2020·Frontiers in Cell and Developmental Biology·Dongsheng Jiang, Karin Scharffetter-Kochanek
Dec 29, 2020·Frontiers in Cell and Developmental Biology·Hazel Y StevensKrishnendu Roy
Apr 13, 2021·Frontiers in Immunology·Yves-Marie PersDanièle Noël
Jul 24, 2021·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Ying-Jie ZhaoJing Li

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