Concise Review: Translating Regenerative Biology into Clinically Relevant Therapies: Are We on the Right Path?

Stem Cells Translational Medicine
Jennifer Simkin, Ashley W Seifert

Abstract

Despite approaches in regenerative medicine using stem cells, bio-engineered scaffolds, and targeted drug delivery to enhance human tissue repair, clinicians remain unable to regenerate large-scale, multi-tissue defects in situ. The study of regenerative biology using mammalian models of complex tissue regeneration offers an opportunity to discover key factors that stimulate a regenerative rather than fibrotic response to injury. For example, although primates and rodents can regenerate their distal digit tips, they heal more proximal amputations with scar tissue. Rabbits and African spiny mice re-grow tissue to fill large musculoskeletal defects through their ear pinna, while other mammals fail to regenerate identical defects and instead heal ear holes through fibrotic repair. This Review explores the utility of these comparative healing models using the spiny mouse ear pinna and the mouse digit tip to consider how mechanistic insight into reparative regeneration might serve to advance regenerative medicine. Specifically, we consider how inflammation and immunity, extracellular matrix composition, and controlled cell proliferation intersect to establish a pro-regenerative microenvironment in response to injuries. Understanding...Continue Reading

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Citations

Feb 9, 2019·Experimental Dermatology·Ting-Xin JiangCheng-Ming Chuong
Nov 11, 2020·Current Opinion in Immunology·Ajoy AloysiusAshley W Seifert

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Methods Mentioned

BETA
amputation
amputations
biopsy

Software Mentioned

Integra

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