Concise review: transplantation of cultured oral mucosal epithelial cells for treating limbal stem cell deficiency-current status and future perspectives

Stem Cells
Tor Paaske Utheim

Abstract

A number of diseases and external factors can deplete limbal stem cells, causing pain and visual loss. Ten years have passed since the first transplantation of cultured oral mucosal epithelial cells in humans, representing the first autologous cell-based therapy for severe bilateral limbal stem cell deficiency. Its steady increase in popularity since then can be attributed to the accumulating evidence of its efficacy in reverting limbal stem cell deficiency. In this review, the focus is on clinical, and to a lesser degree laboratory, features of cultured oral mucosal epithelial transplants over the past 10 years. Comparisons with other available technologies are made. Avenues for research to stimulate further improvements in clinical results and allow worldwide distribution of limbal stem cell therapy based on oral mucosal cells are discussed. These include storage and transportation of cultured oral mucosal epithelial sheets and in vivo culture of oral mucosal epithelial cells.

References

May 1, 1989·Ophthalmology·K R Kenyon, S C Tseng
Feb 4, 1999·The British Journal of Ophthalmology·H S Dua
Apr 24, 2001·The British Journal of Ophthalmology·D F AndersonS C Tseng
Jul 27, 2001·Archives of Ophthalmology·C M MangioneUNKNOWN National Eye Institute Visual Function Questionnaire Field Test Investigators
Sep 17, 2004·The New England Journal of Medicine·Kohji NishidaYasuo Tano
Jul 29, 2005·The American Journal of Pathology·Tetsuya KawakitaScheffer C G Tseng
Feb 7, 2006·American Journal of Ophthalmology·Tsutomu InatomiShigeru Kinoshita
Aug 1, 2006·American Journal of Ophthalmology·Stephen C Pflugfelder
Aug 29, 2006·Investigative Ophthalmology & Visual Science·Hidetoshi TaniokaShigeru Kinoshita
Sep 26, 2006·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Daisuke MurakamiTeruo Okano
Sep 26, 2006·Molecular Reproduction and Development·Xueyi YangZhongying Dou
Nov 15, 2006·Archives of Ophthalmology·Leonard P K AngShigeru Kinoshita
May 1, 2007·Regenerative Medicine·Julie T DanielsShankar Seetharaman
Aug 7, 2007·Ophthalmology·J S López-GarcíaJ Murube
Jan 1, 1944·The British Journal of Ophthalmology·I Mann
Jan 4, 2008·Investigative Ophthalmology & Visual Science·Wei LiScheffer C G Tseng
Oct 16, 2008·The Journal of Pathology·G PellegriniM De Luca
Mar 17, 2009·American Journal of Ophthalmology·Yayoi ArakiShigeru Kinoshita
May 5, 2009·Ophthalmology·Harminder S DuaDalia G Said
May 14, 2009·Seminars in Ophthalmology·Pauline LimUla V Jurkunas
May 22, 2009·Investigative Ophthalmology & Visual Science·Hung-Chi Jesse ChenDavid Hui-Kang Ma
Aug 8, 2009·Investigative Ophthalmology & Visual Science·Jun ShimazakiYoshiyuki Satake
Aug 28, 2009·Investigative Ophthalmology & Visual Science·Ewa Anna Meyer-BlazejewskaUrsula Schlötzer-Schrehardt
Jan 23, 2010·Clinical & Experimental Ophthalmology·Lingyi LiangZuguo Liu
May 28, 2010·Journal of Cellular Physiology·Sajjad AhmadUla Jurkunas
Jun 25, 2010·The New England Journal of Medicine·Paolo RamaGraziella Pellegrini

❮ Previous
Next ❯

Citations

Sep 8, 2015·Journal of Functional Biomaterials·Amer SehicTor Paaske Utheim
Feb 2, 2016·Survey of Ophthalmology·Rajat JainVirender S Sangwan
May 26, 2017·Journal of Dental Research·Q L XuA D Le
Mar 5, 2016·Journal of Functional Biomaterials·Tor Paaske UtheimAmer Sehic
Jun 5, 2018·Cell Transplantation·Soraya Rasi GhaemiNicolas H Voelcker
Oct 26, 2018·Stem Cell Research & Therapy·Koushik ChakrabartyArkasubhra Ghosh
Mar 25, 2017·Current Eye Research·Barbara ZsebikLili Takács
Jan 4, 2017·Stem Cells International·Nuria Nieto-NicolauRicardo P Casaroli-Marano
Dec 6, 2019·Stem Cells Translational Medicine·Catherine J JacksonTor P Utheim
Jul 28, 2017·Stem Cells·Mehrnoosh SaghizadehAlexander V Ljubimov
Apr 21, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Junyi WangLixin Xie
Nov 29, 2020·Tissue & Cell·Hamed NosratiMohammad Khodaei
Jul 3, 2021·International Journal of Molecular Sciences·Sonia LópezHiginio Arzate

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.