Concise Review: Using Fat to Fight Disease: A Systematic Review of Nonhomologous Adipose-Derived Stromal/Stem Cell Therapies

Stem Cells
Marjorie E BatemanBruce A Bunnell

Abstract

The objective of this Review is to describe the safety and efficacy of adipose stem/stromal cells (ASC) and stromal vascular fraction (SVF) in treating common diseases and the next steps in research that must occur prior to clinical use. Pubmed, Ovid Medline, Embase, Web of Science, and the Cochrane Library were searched for articles about use of SVF or ASC for disease therapy published between 2012 and 2017. One meta-analysis, 2 randomized controlled trials, and 16 case series were included, representing 844 human patients. Sixty-nine studies were performed in preclinical models of disease. ASCs improved symptoms, fistula healing, remission, and recurrence rates in severe cases of inflammatory bowel disease. In osteoarthritis, ASC and SVF improved symptom-related, functional, radiographic, and histological scores. ASC and SVF were also shown to improve clinical outcomes in ischemic stroke, multiple sclerosis, myocardial ischemia, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, chronic liver failure, glioblastoma, acute kidney injury, and chronic skin wounds. These effects were primarily paracrine in nature and mediated through reduction of inflammation and promotion of tissue repair. In the majority of hu...Continue Reading

References

Apr 19, 2005·Cancer Research·Akira NakamizoFrederick F Lang
Feb 21, 2006·Trends in Biotechnology·John K FraserMarc H Hedrick
Jul 1, 2006·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Xiaobing FuZhiyong Sheng
May 15, 2007·Circulation Research·Jeffrey M GimbleBruce A Bunnell
Apr 19, 2008·Journal of Cellular and Molecular Medicine·Leonardo A Meza-ZepedaPhilippe Collas
Jan 28, 2009·Nature Reviews. Immunology·Antonio UccelliVito Pistoia
May 21, 2009·European Journal of Gastroenterology & Hepatology·Pedram KharazihaMasoud Soleimani
Jun 15, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Seung Ah ChoiSeung-Ki Kim
Jul 7, 2011·International Journal of Cancer. Journal International Du Cancer·Veronika AltanerovaCestmir Altaner
Nov 8, 2011·Cell Stem Cell·Tamra Lysaght, Alastair V Campbell
Dec 30, 2011·American Journal of Physiology. Renal Physiology·Jin Hyun KimSe-Ho Chang
Apr 19, 2012·Annals of Plastic Surgery·Sherry S CollawnLouise T Chow
Nov 23, 2012·Chest·Daniel J WeissDonald P Tashkin
Dec 1, 2012·Stem Cells Translational Medicine·Scott MaxsonMichelle A Leroux
May 21, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Akihiro SekiShuichi Kaneko
Aug 29, 2013·Stem Cells Translational Medicine·Julie A SemonBruce A Bunnell
Sep 17, 2013·International Journal of Cancer. Journal International Du Cancer·Cestmir AltanerBoris Mravec
Oct 8, 2013·Cytotherapy·Marieke Roemeling-van RhijnMartin J Hoogduijn
Dec 12, 2013·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Yong-Gon KohJee-Eun Yeo

❮ Previous
Next ❯

Citations

May 18, 2019·Stem Cells Translational Medicine·Cesario V Borlongan
Dec 5, 2019·Stem Cells and Development·Ricardo L RodriguezJeffrey M Gimble
Mar 25, 2020·Cell Transplantation·Bocheng ZhangWeiguo Zhang
Apr 6, 2019·Current Opinion in Urology·Sheila MacNeilEmma Mironska
May 10, 2019·Journal of Extracellular Vesicles·Kenneth W WitwerSai Kiang Lim
Jul 7, 2019·International Journal of Molecular Sciences·Maria Giovanna ScioliAugusto Orlandi
Mar 7, 2020·Frontiers in Oncology·Roberta Fajka-BojaRóbert L Katona
Nov 8, 2018·International Journal of Molecular Sciences·Chiara ArgentatiSabata Martino
Jan 24, 2019·International Journal of Molecular Sciences·Ingo GerhauserAndreas Beineke
May 31, 2019·International Journal of Molecular Sciences·Giovanna DesandoBrunella Grigolo
Jan 24, 2020·Frontiers in Oncology·Virgínea de Araújo FariasJosé Mariano Ruiz de Almodóvar
May 5, 2020·Frontiers in Cell and Developmental Biology·Simona CeccarelliCinzia Marchese
Jun 14, 2019·Stem Cells International·Mimmi PatrikoskiSusanna Miettinen
Mar 28, 2019·Stem Cells International·Sara NavaGiulio Alessandri
Jun 28, 2019·International Journal of Molecular Sciences·Marta Torres-TorrillasJoaquin J Sopena
Jan 17, 2020·Plastic and Reconstructive Surgery. Global Open·Inna SolodeevNir Shani
Apr 13, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Shelley S PollyLinda A Dahlgren
Jan 4, 2021·Cell Biochemistry and Function·Mariane Izabella Abreu de MeloDawidson Assis Gomes
Dec 25, 2019·Molecular Therapy. Methods & Clinical Development·Rafael Soares LindosoFederica Collino
Oct 27, 2020·Frontiers in Cell and Developmental Biology·Hongyan LuNatalia V Bogatcheva
Nov 7, 2020·Frontiers in Immunology·Thomas DaubonMaya Saleh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Cancer Stem Cells in Glioblastoma

Glioblastoma is the most common and aggressive type of brain tumor. It contains a population of tumor initiating stem cell-like cells known as cancer stem cells. Investigations are ongoing into these cancer stem cells found in these solid tumors which are highly resistance to treatment. Here is the latest research on cancer stem cells in glioblastoma.

Related Papers

Annals of Plastic Surgery
Navid Mohamadpour ToyserkaniJens Ahm Sørensen
Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA
Eoghan T HurleyJohn G Kennedy
© 2022 Meta ULC. All rights reserved