PMID: 9536958Apr 16, 1998Paper

Conclusive evidence of endotoxaemia in biliary obstruction

Gut
W D ClementsB J Rowlands

Abstract

Endotoxaemia is implicated in the pathophysiology of obstructive jaundice. The EndoCab enzyme linked immunosorbent assay (ELISA) is a novel assay which measures endogenous antibody (IgG) to the inner core region of circulating endotoxins (ACGA). To investigate the significance of endotoxaemia in biliary obstruction using the EndoCab assay and assess the specificity of the humoral response to endotoxin compared with an exogenous antigenic challenge (tetanus toxoid, TT). Three groups of adult male Wistar rats were studied: no operation, sham operation, and bile duct ligation for 21 days (BDL). In the second study, rats rats received prior immunisation with TT. In the preliminary experiment, plasma ACGA was significantly increased in the BDL group (306.6 (18.3)% versus 119.9 (6.7)% and 105.2 (4.6)% in the sham and no operation groups, respectively; p < 0.001). Although the mean endotoxin concentration in the BDL group was greater than that in the control groups this was not significant. There was a strong positive correlation between ACGA and endotoxin concentrations (p = 0.0021). In the second study mean ACGA after 21 days of BDL was significantly elevated (267.1 (31.2)% versus 101.6 (21.2)% at baseline, p < 0.0001). ACGA was una...Continue Reading

References

Jun 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M H BemelmansW A Buurman
Feb 1, 1991·Current Opinion in Immunology·S D Wright
Jun 1, 1991·HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery·T Diamond, B J Rowlands
Jan 1, 1990·American Journal of Surgery·E A DeitchR D Specian
Sep 1, 1988·Reviews of Infectious Diseases·C L WellsR L Simmons
Jan 1, 1988·Annals of Surgery·M Trede, G Schwall
Mar 1, 1988·The British Journal of Surgery·J D GreigN A Matheson
Sep 1, 1988·The Journal of Surgical Research·D W VaneJ L Grosfeld
Aug 1, 1986·The British Journal of Surgery·J N ThompsonL H Blumgart
Oct 1, 1986·The British Journal of Surgery·J A Pain, M E Bailey
Jun 30, 1966·Annals of the New York Academy of Sciences·R C Skarnes
Dec 1, 1974·Archives of Surgery·E N Wardle
Nov 21, 1970·British Medical Journal·E N Wardle, N A Wright
Jan 1, 1984·Annals of Surgery·S KatzT R Weber
May 1, 1981·American Journal of Surgery·J P ArnaudM Adloff
Dec 1, 1984·The Journal of Infectious Diseases·J Cohen, J S McConnell
Mar 1, 1984·The British Journal of Surgery·C P ArmstrongG C Davies
Sep 1, 1983·The British Journal of Surgery·S L BlameyD C Carter
Oct 1, 1982·The British Journal of Surgery·M S FletcherV V Kakkar
Oct 1, 1980·The Australian and New Zealand Journal of Surgery·D R Hunt
Jan 1, 1981·American Journal of Surgery·H A PittT R Gadacz
May 1, 1982·World Journal of Surgery·V CardosoM J Vaz
Sep 1, 1982·American Journal of Surgery·D R HuntL H Blumgart
May 1, 1994·The Journal of Experimental Medicine·K MatsuuraS Yamamoto
Jul 12, 1995·JAMA : the Journal of the American Medical Association·A S GoldieJ C Howie
Jul 1, 1993·The British Journal of Surgery·W D ClementsB J Rowlands
Aug 1, 1994·The Journal of Surgical Research·C E Scott-Conner, J B Grogan
Dec 1, 1993·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·M G MythenS J Machin
Feb 1, 1993·Archives of Surgery·W D ClementsB J Rowlands

❮ Previous
Next ❯

Citations

Aug 10, 2006·Pediatric Surgery International·Hayrettin OzturkHuseyin Buyukbayram
Jul 13, 2001·European Journal of Pharmacology·K NamiranianA R Dehpour
Jun 18, 2002·European Journal of Pharmacology·Ahmad R DehpourAbolhasan Ahmadiani
Oct 26, 1999·Journal of Gastroenterology and Hepatology·M TraunerR E Stauber
May 17, 2001·Journal of Gastroenterology and Hepatology·F KimuraH Yoshitome
Jun 23, 2006·Critical Care Medicine·Andrea GiacomettiGiorgio Scalise
Nov 29, 2012·The Cancer Journal·Johanna A M G TolDirk J Gouma
Aug 17, 2005·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Ian R Poxton
Dec 31, 2008·World Journal of Gastroenterology : WJG·Stelios F Assimakopoulos, Constantine E Vagianos
Jul 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Catherine StedmanMichael Downes
Aug 30, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·N A van der GaagD J Gouma
Oct 1, 2010·European Journal of Gastroenterology & Hepatology·Adam UsluYavuz Coşkun
Oct 27, 2011·European Journal of Gastroenterology & Hepatology·Stephen A BadgerMark A Taylor
Sep 2, 2008·Biochemical and Biophysical Research Communications·Erwin GäbeleClaus Hellerbrand
Oct 15, 2003·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Yoshiya ItoRobert S McCuskey
Dec 24, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Steven M KerfootMark G Swain
Jul 6, 2004·The Journal of Surgical Research·Jiin-Haur ChuangTsu-Kung Lin
Sep 13, 2005·The Journal of Surgical Research·J S WhiteT Diamond
Dec 12, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·H RastegarA R Dehpour
May 16, 2015·Canadian Journal of Physiology and Pharmacology·Sattar OstadhadiAhmad-Reza Dehpour
Mar 3, 2015·Seminars in Oncology·Harkirat Singh, Ali A Siddiqui
Jan 17, 2013·Clinical and Molecular Hepatology·Yeon Seok Seo, Vijay H Shah
Jun 19, 2004·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Kaya YorganciIskender Sayek
Aug 5, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·Ying-Hsien HuangChao-Long Chen
Mar 2, 2006·European Journal of Clinical Investigation·S F AssimakopoulosC E Vagianos
Feb 9, 2006·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·J S WhiteT Diamond
Dec 17, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Juan P ArabVijay H Shah
Jul 25, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shinji HashimotoHideki Ohdan
May 28, 2017·Hepatology International·Juan P ArabVijay H Shah
Jul 3, 2021·International Journal of Molecular Sciences·Norihisa NishimuraHitoshi Yoshiji

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.