PMID: 2492271Jan 1, 1989Paper

Concomitant 5-fluorouracil infusion, mitomycin C and radical radiation therapy in esophageal squamous cell carcinoma

International Journal of Radiation Oncology, Biology, Physics
A ChanK Arthur

Abstract

This is a retrospective comparison of patients with unresected esophageal squamous cell carcinoma treated by radiation therapy and chemotherapy (21 patients) versus radiation therapy alone (34 patients). Pretreatment characteristics were comparable in both groups. In the combined modality group, treatment was given in split courses with concomitant radiation therapy (20 to 25 Gy in 10 fractions on days 1-12 and days 42-54) and chemotherapy (bolus Mitomycin C on day 1; 96 hr. of continuous 5 Fluorouracil infusion on days 1-4 and days 42-46). There was improvement in local disease control with the combined modality approach. Initial complete response was achieved in 86% of the radiation and chemotherapy group, versus 57% of the radiation alone group. The one-year local relapse-free rate was 67% versus 35%, and 2 year rate was 41% versus 28%. (p less than 0.05). The 1-year and 2-year survival was 64% and 32% respectively, for the radiation and chemotherapy group, versus 28% and 10% respectively for the radiation alone group (p less than 0.05). The majority of patients had disease relapsed, 81% of the combined modality group and 97% of the radiation alone group. However, the pattern of failure was different in the two groups. In th...Continue Reading

Citations

Jul 15, 1995·International Journal of Radiation Oncology, Biology, Physics·B H BurmeisterD S Lamb
Jan 15, 1996·International Journal of Radiation Oncology, Biology, Physics·J P MalhaireA Volant
Sep 7, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·C R HayterK Schulze
Mar 26, 2003·International Journal of Radiation Oncology, Biology, Physics·Vicharn LorvidhayaEkachai Visetsiri
Apr 16, 1998·International Journal of Radiation Oncology, Biology, Physics·M MurakamiH Takeda
Jan 23, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J I Geh
Jun 1, 2002·American Journal of Clinical Oncology·Michael JeffordMichael J Guiney
Sep 16, 1999·International Journal of Radiation Oncology, Biology, Physics·A Chan, A Wong
Jan 1, 1991·International Journal of Radiation Oncology, Biology, Physics·L R CoiaG E Hanks
Mar 1, 1997·Cancer Treatment Reviews·T C Kok
Nov 5, 1997·The Surgical Clinics of North America·C R Thomas
Nov 19, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Arif Deniz OrduKhashayar Fakhrian
Nov 1, 1994·Australasian Radiology·R HuiI O'Rourke
Mar 1, 1995·World Journal of Surgery·U FinkJ R Siewert
Feb 20, 1998·The American Journal of Hospice & Palliative Care·R Tan, A Young
Jul 1, 1994·Current Problems in Cancer·L R Coia, E R Sauter

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
T KeaneJ C Cooper
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
T ZenoneJ P Gerard
International Journal of Radiation Oncology, Biology, Physics
A M HerskovicB White
© 2022 Meta ULC. All rights reserved