Concomitant and decoupled effects of cigarette smoke and SCAL1 upregulation on oncogenic phenotypes and ROS detoxification in lung adenocarcinoma cells.

Scientific Reports
Carmela Rieline V CruzReynaldo L Garcia


Lung cancer is the leading cause of cancer deaths worldwide, with smoking as its primary predisposing factor. Although carcinogens in cigarettes are known to cause oncogenic DNA alterations, analyses of patient cohorts revealed heterogeneous genetic aberrations with no clear driver mutations. The contribution of noncoding RNAs (ncRNAs) in the pathogenesis of lung cancer has since been demonstrated. Their dysregulation has been linked to cancer initiation and progression. A novel long noncoding RNA (lncRNA) called smoke and cancer-associated lncRNA 1 (SCAL1) was recently found upregulated in smoke-exposed adenocarcinomic alveolar epithelial cells. The present study characterized the phenotypic consequences of SCAL1 overexpression and knockdown using A549 cells as model system, with or without prior exposure to cigarette smoke extract (CSE). Increase in SCAL1 levels either by CSE treatment or SCAL1 overexpression led to increased cell migration, extensive cytoskeletal remodeling, and resistance to apoptosis. Further, SCAL1 levels were negatively correlated with intracellular levels of reactive oxygen species (ROS). In contrast, SCAL1 knockdown showed converse results for these assays. These results confirm the oncogenic function ...Continue Reading


Mar 13, 2003·Molecular Biology of the Cell·Eugene W KruegerMark A McNiven
Feb 14, 2004·Science·Amin RustomHans-Hermann Gerdes
Sep 6, 2005·Cancer Research·Marco PelusoPaolo Vineis
Aug 24, 2006·Biochimica Et Biophysica Acta·Hideki Yamaguchi, John Condeelis
Apr 9, 2008·FEBS Letters·Laura M Machesky
Dec 3, 2009·The Journal of Cell Biology·Peter Friedl, Katarina Wolf
Oct 7, 2011·Cell Adhesion & Migration·Antti ArjonenJohanna Ivaska
Apr 20, 2012·Frontiers in Physiology·Ludovica MarzoChiara Zurzolo
Aug 29, 2012·Molecular and Cellular Biology·Jing-Ling HoonCheng-Gee Koh
Sep 5, 2012·International Journal of Cancer. Journal International Du Cancer·Stephen S Hecht
Oct 13, 2012·Communicative & Integrative Biology·Emil LouSubbaya Subramanian
Feb 26, 2013·Free Radical Biology & Medicine·Suryakant K NitureAnil K Jaiswal
May 16, 2013·American Journal of Respiratory Cell and Molecular Biology·Philip ThaiReen Wu
Sep 12, 2013·Redox Biology·Emilia KansanenAnna-Liisa Levonen
Feb 8, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Mantang QiuRong Yin
Jul 20, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anna KarlssonJohan Staaf
Aug 15, 2014·Genome Biology·Nicole M WhiteChristopher A Maher
Aug 19, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jie LuoDi Zheng
Feb 12, 2015·Cancer Cell·Paul T Schumacker
May 6, 2015·Proceedings of the National Academy of Sciences of the United States of America·Xiaowei ShaoG V Shivashankar
May 15, 2015·Environmental Health and Preventive Medicine·Zhihai ChenJian Tong
Jul 8, 2017·Cancers·Elena MadrazoJavier Redondo-Muñoz
Sep 21, 2017·Toxicology·Marcello CeppiMarco E M Peluso
Dec 1, 2017·Current Cancer Drug Targets·Pragyaparamita SahuLuna Samanta
Mar 2, 2018·Journal of Virology·Mirosława PanasiukKrystyna Bieńkowska-Szewczyk
Jul 23, 2018·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Zaosong ZhengWenlian Xie
Sep 13, 2018·Journal of Cellular Physiology·Rahul MittalVasanti M Jhaveri
Dec 28, 2018·Journal of Cellular and Molecular Medicine·Yun LouGuoqiang Li
Mar 5, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Liang ZhangHai-Rong Yao
Jul 14, 2019·Journal of Experimental & Clinical Cancer Research : CR·Ang ZhengFeng Jin
Sep 24, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Junlin ChiYujian Zeng
Dec 5, 2019·Frontiers in Oncology·Shi-Jia JinWei-Lin Jin

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