PMID: 2105833Feb 1, 1990Paper

Concomitant continuous infusion chemotherapy and radiation

Cancer
M Rotman, H Aziz

Abstract

Attempts to duplicate the cytotoxic effect of oxygen on radioresistant tissues spurred a search by radiation oncologists for other radiosensitizing techniques. This led to large-scale investigations using neutrons and other heavy particle radiations, hyperthermia, altered fractionation schedules, and the systemic use of the halogenated pyrimidines and the electron-affinic compounds. Unfortunately, the promise that the nitroimidazole compounds would selectively sensitize the radioresistant tumor cells and prove to be an effective systemic agent has not been borne out in clinical trials thus far. Existing pharmokinetic and cytokinetic studies have suggested that continuous infusion chemotherapy given concomitantly (CCIC) with irradiation (RT) acts synergistically, resulting in a significant increase in tumor cell killing. These observations have been supported by clinical research studies treating certain epithelial cancers that have resulted in considerably higher locoregional control rates and improved survival. Although initially used in treatment of only advanced or inoperable epithelial carcinomas, CCIC and RT are now being employed in the treatment of lower staged cancers as an organ-sparing procedure. Carcinoma of the anus...Continue Reading

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Citations

Jan 6, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ananya ChoudhuryRichard A Cowan
Sep 28, 1998·Diseases of the Colon and Rectum·A Habr-GamaJ Gama-Rodrigues
Dec 18, 2001·Journal of Clinical Gastroenterology·David Blumberg, Ramesh K Ramanathan
Apr 30, 1998·Journal of Magnetic Resonance Imaging : JMRI·S H NgJ T Chang
Dec 10, 1997·International Journal of Radiation Oncology, Biology, Physics·J A KoutcherD S Martin

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