Concomitant excitation and tension development are required for myocellular gene expression and protein synthesis in rat skeletal muscle.

Acta Physiologica
Emil RindomFrank Vincenzo de Paoli

Abstract

Loading-induced tension development is often assumed to constitute an independent cue to initiate muscle protein synthesis following resistance exercise. However, with traditional physiological models of resistance exercise, changes in loading-induced tension development also reflect changes in neural activation patterns, and direct evidence for a mechanosensitive mechanism is therefore limited. Here, we sought to examine the importance of excitation and tension development per se on initiation of signalling, gene transcription and protein synthesis in rat skeletal muscle. Isolated rat extensor digitorum longus muscles were allocated to the following interventions: (a) Excitation-induced eccentric contractions (ECC); (b) Passive stretching without excitation (PAS); (c) Excitation with inhibition of contractions (STIM + IMA ) and; (d) Excitation in combination with both inhibition of contractions and PAS (STIM + IMA  + PAS). Assessment of transcriptional and translational signalling, gene transcription and acute muscle protein synthesis was compared in stimulated vs contra-lateral non-stimulated control muscle. Protein synthesis increased solely in muscles subjected to a combination of excitation and tension development (ECC and...Continue Reading

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Citations

Dec 19, 2020·Acta Physiologica·Kathrin Groeneveld
Jan 24, 2021·Acta Physiologica·Pontus B Persson, Anja B Persson

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