Concomitant Fahr's syndrome and thoracic ossification of the posterior longitudinal ligament caused by idiopathic hypoparathyroidism - case report

BMC Musculoskeletal Disorders
Ikchan JeonSang Woo Kim

Abstract

Fahr's syndrome presenting multiple and symmetric calcification of basal ganglia and cerebral cortex is rare, and idiopathic hypoparatyroidism is known as one of the causes. The relationship between ossification of posterior longitudinal ligament (OPLL) and idiopathic hypoparatyroidism is also reported in a few cases. Here, we report a patient presenting concomitant Fahr's syndrome and thoracic OPLL developed by idiopathic hypoparatyroidism. 53-year-old female patient presented myelopathic sign including gait disturbance and both leg weakness (Grade 3) for 4 months after slip down, and has the history of anti-epileptic medication for several years. Magnetic resonance imaging revealed cord compression by the mixed-type OPLL from T5 to T9, and decompressive surgery was planned. Sudden onset generalized tonic-clonic seizure attack developed before the surgery. Hypocalcemia (3.7 mg/dL) with QT prolongation on electrocardiogram, hypomagnesemia (1.4 mg/dL), hyperphosphatemia (7.7 mg/dL), hypoparathyroidism, and normal range of vitamin D was noted. Brain study showed Fahr's syndrome with multiple and symmetric calcification of basal ganglia, cerebral cortex, and cerebellum. Decompressive laminectomy was performed after transient corre...Continue Reading

References

Mar 1, 1989·Clinical Radiology·R G Lambert, E J Becker
Aug 1, 1984·Metabolism: Clinical and Experimental·T OkazakiE Ogata
Feb 1, 2005·Joint, Bone, Spine : Revue Du Rhumatisme·Cengiz KorkmazAyşegül Binboğa
Dec 17, 2009·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Selman UnverdiSacit Turanl
Dec 8, 2010·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Maryam I KhanMimi I Hu
Oct 9, 2013·Orphanet Journal of Rare Diseases·Shafaq SaleemMuhammad Asim Khan Rehmani
Jan 25, 2014·Journal of Rehabilitation Research and Development·Christina V OlesonTingting Zhan
Sep 10, 2014·Indian Journal of Anaesthesia·Ashish ChakravartyYatin Mehta
Jun 5, 2015·Journal of Bone and Mineral Metabolism·Masafumi KashiiHideki Yoshikawa
Feb 6, 2018·Surgical Neurology International·Amir H SohailQamar Masood

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Citations

Nov 22, 2019·World Journal of Clinical Cases·Yuan-Yuan ZhouHong-Mei Qiu

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