Concomitant Graves' disease and primary hyperparathyroidism. Influence of hyperthyroidism on serum calcium and parathyroid hormone

The American Journal of Medicine
R AremL E Mallette

Abstract

Two patients with coexistent Graves' disease and primary hyperparathyroidism were studied during medical treatment of their hyperthyroidism. Serum free calcium level was initially quite elevated (1.61 and 1.71 mM, normal 1.12 to 1.28 mM), but immunoreactive parathyroid hormone values were only slightly increased. The immunoreactive parathyroid hormone values of 153 and 173 nleq/ml (normal less than 150 nleq/ml) were far lower than expected in hyperparathyroid patients with a similar degree of hypercalcemia. As the patients became euthyroid during thionamide treatment, calcium values decreased to 1.39 and 1.61 mM, respectively, and parathyroid hormone increased to values clearly suggestive of hyperparathyroidism (454 and 229 nleq/ml, respectively). Parathyroidectomy and subtotal thyroidectomy cured both the hyperparathyroidism and the thyrotoxicosis in each case. These observations suggest that thyroid hormone had potentiated the osteoclastic effects of parathyroid hormone and that the resulting exacerbation of hypercalcemia had produced a relative suppression of hormone secretion by the abnormal parathyroid tissue.

References

Sep 1, 1976·The Journal of Clinical Investigation·G R MundyL G Raisz
Oct 1, 1978·The Journal of Clinical Endocrinology and Metabolism·R K RudeF R Singer
Mar 1, 1978·The American Journal of the Medical Sciences·M N Shahshahani, G M Palmieri
Jul 1, 1975·Metabolism: Clinical and Experimental·J H CastroL Klein
Jul 23, 1966·British Medical Journal·J K Nelson, D R Hadden
Sep 1, 1966·Annals of Internal Medicine·J D Baxter, P K Bondy
Jun 7, 1969·Lancet·R M BuckleJ E Middleton
Jul 1, 1972·Clinical Endocrinology·T M MurrayJ T Potts
Jun 1, 1974·The Journal of Clinical Endocrinology and Metabolism·R Bouillon, P De Moor
Jul 1, 1973·Clinics in Endocrinology and Metabolism·D A SmithG M Wilson
Oct 1, 1968·Metabolism: Clinical and Experimental·M M Ahuja, I J Chopra
Jul 1, 1970·Postgraduate Medical Journal·A J Richards
Nov 1, 1970·The British Journal of Surgery·K M Rao
Jun 1, 1966·The Journal of Clinical Investigation·J E JonesE B Flink
Jul 1, 1981·The Journal of Clinical Endocrinology and Metabolism·S J MarxL E Mallette
Oct 1, 1981·The American Journal of Medicine·E M BrownS P Marynick
Nov 1, 1980·The Journal of Clinical Endocrinology and Metabolism·B HaldimannS G Massry
Mar 1, 1961·Acta Medica Scandinavica·H GADEHOLT
May 1, 1961·Annals of Internal Medicine·C E JACKSONH D CAYLOR
Nov 1, 1959·The American Journal of Medicine·B FRAME, R H DURHAM
Jul 1, 1963·Acta Medica Scandinavica·P TORSTI, B A LAMBERG
Mar 1, 1964·Annals of Surgery·L R BRYANTW A ALTEMEIER

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Citations

Feb 20, 2003·Clinical Nuclear Medicine·Kottekkattu K BalanGordon C Wishart
Jan 1, 1997·Postgraduate Medical Journal·S VijayaraghavanJ P Monson
Apr 1, 1991·Journal of Endocrinological Investigation·D M McGowanI Shperling
Oct 1, 1993·Journal of the American Geriatrics Society·H T Blumenthal, I B Perlstein
Dec 17, 2014·Endocrine Pathology·Shuanzeng WeiVirginia A LiVolsi
Sep 19, 2003·Rheumatology International·Ihsan UstünSelma Karaahmetoğlu
Jun 27, 2008·Yonsei Medical Journal·Hai-Jin KimChul-Woo Ahn
Jan 16, 2008·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Teck-Kim KhooRobert A Wermers
Jul 22, 2005·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Xiangbing Wang, Maria Fernandez Renedo
Apr 6, 2021·The Journal of Surgical Research·Gianina C Hernández-MárquezHerbert Chen

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