Concomitant hydroxyurea plus radiotherapy versus radiotherapy for carcinoma of the uterine cervix: a systematic review

Cancer Treatment Reviews
R P SymondsC J Williams

Abstract

We identified eight randomised control trials of hydroxyurea and radiation versus radiotherapy alone (six published in full and two abstracts). Most concluded that outcomes were improved by use of hydroxyurea. However, methodological problems associated with these trials included small sample size, a large number of patient exclusions post randomisation, differing outcome definitions, subgroup analyses of already small numbers of patients and questionable rules for censoring, particularly a failure to include treatment related deaths in the survival analysis. All but two studies were of less than 50 patients. Patients were excluded from some analyses for treatment related reasons. The exclusion of such patients undoubtedly altered the conclusions of the studies. Even if there was a survival advantage attributed to hydroxyurea, overall survival was somewhat poor. We found the evidence regarding the use of hydroxyurea and radiotherapy to be inadequate for assessing its role in the treatment of cervical cancer.

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Citations

Feb 28, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C M NuttingK J Harrington
May 26, 2006·Radiation Oncology·Myrna CandelariaAlfonso Dueñas-Gonzalez
Nov 13, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·UNKNOWN Chemoradiotherapy for Cervical Cancer Meta-Analysis Collaboration
Apr 1, 2009·Seminars in Oncology·Lisa Barbera, Gillian Thomas
Jun 17, 2016·The Journal of Chemical Physics·S E HuberS Denifl
Jun 24, 2008·Clinical Oncology : a Journal of the Royal College of Radiologists·J F TierneyP Symonds
Oct 22, 2008·Seminars in Oncology·George A Omura, UNKNOWN Gynecologic Oncology Group
Jan 22, 2010·The Cochrane Database of Systematic Reviews·UNKNOWN Chemoradiotherapy for Cervical Cancer Meta-analysis Collaboration (CCCMAC)
Jul 22, 2005·The Cochrane Database of Systematic Reviews·J GreenM Collingwood
Mar 9, 2010·Drugs·Alfonso Dueñas-GonzálezDéborah Martínez-Baños
May 6, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christopher A BarkerPhilip J Tofilon

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