Concomitant immunity in a rodent model of filariasis: the infection of Meriones unguiculatus with Acanthocheilonema viteae

The Journal of Parasitology
Sethu RajakumarRichard Lucius

Abstract

In an attempt to study the occurrence of concomitant immunity in filarial infections, jirds (Meriones unguiculatus) were experimentally infected with Acanthocheilonema viteae, and patent animals were superinfected with a defined dose of A. viteae stage 3 larvae (L3). Infected animals harbored significantly less worms deriving from the superinfection than the control group (P < 0.05, 56.2%, and 63.4% protection), as shown by analysis of female worms 6 wk after superinfection on the basis of their developmental status and their length. This protection was not due to contact with L3 antigens because a significant reduction of worm burdens deriving of a superinfection was also observed after subcutaneous implantation of a single female worm (P < 0.05, 40.2% and 64.9% protection). The induced protective responses target L3 and restrict their migration because an established infection resulted in a reduction of L3 recovery (95.6% and 94.3%, P < 0.001) from tissues of jirds at day 5 after superinfection. Other data show that L3 from a superinfection are trapped within eosinophil-rich granulomas, which is likely to create unfavorable conditions for the worms and to lead to later death. Taken together, established A. viteae-infections p...Continue Reading

References

Jan 1, 1974·Transactions of the Royal Society of Tropical Medicine and Hygiene·J AndersonT F de Marshall
Oct 6, 1969·Annals of the New York Academy of Sciences·S R Smithers, R J Terry
Jan 1, 1984·Transactions of the Royal Society of Tropical Medicine and Hygiene·F Engelbrecht, H Schulz-Key
Jan 1, 1981·Transactions of the Royal Society of Tropical Medicine and Hygiene·M Tanner, N Weiss
Jul 1, 1993·Parasite Immunology·E DevaneyA Egan
Mar 2, 1999·Advances in Parasitology·J AndreassenC Bryant
Dec 26, 2001·Proceedings. Biological Sciences·S P Brown, B T Grenfell
Sep 19, 2003·International Journal for Parasitology·S Hartmann, R Lucius
Aug 1, 1995·Parasitology Today·D RichterF R Matuschka
Sep 14, 2004·Immunological Reviews·Rick M MaizelsJudith E Allen
Jan 1, 1993·Parasitology Today·P Hagan, H A Wilkins

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Citations

Jul 5, 2013·Clinical Microbiology Reviews·C Paul MorrisEdward Mitre
Sep 10, 2015·Journal of Evolutionary Biology·S Kada, S Lion
May 5, 2009·Trends in Parasitology·Nicole Mideo
Jun 24, 2008·Trends in Parasitology·Hans P DuerrMartin Eichner
Mar 19, 2014·Trends in Parasitology·David H MolyneuxLouise A Kelly-Hope
Jun 24, 2016·Journal of Fish Diseases·M S UgelvikA Skorping

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