Concomitant myeloproliferative and lymphoproliferative neoplasms, distinct progenitors: A case report and review of the literature

Molecular and Clinical Oncology
Filipa MousinhoFernando Lima

Abstract

Patients with a Philadelphia chromosome-negative myeloproliferative neoplasm may develop a lymphoproliferative disorder; however, the clinical and molecular determinants and the chronological onset of the two events remain unknown. We herein report the case of a 64-year-old man with concomitant diagnosis of high-risk essential thrombocythemia with evidence of a thrombotic event and high-count monoclonal B-cell lymphocytosis (high-count MBL). The patient harbored a JAK2V617F mutation and one of the most common genetic alterations found in chronic lymphocytic leukemia (CLL) (del 13q), which may represent a sign of disease progression. He was initiated on cytoreductive therapy with hydroxyurea 500 mg 3 times per week and hypocoagulation treatment, and is currently under regular surveillance of MBL without CLL criteria.

References

Sep 20, 2006·Annals of Internal Medicine·Tait D ShanafeltNeil E Kay
Nov 16, 2006·European Journal of Haematology·Kais HusseinHans Kreipe
Jul 25, 2009·Leukemia Research·Srinivas KodaliJen Chin Wang
Oct 22, 2014·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Adrian P TrifaIoan V Pop
Jun 5, 2017·Revista brasileira de hematologia e hemoterapia·Sara DuarteAmélia Pereira
Jan 30, 2018·American Journal of Hematology·Monia MarchettiTiziano Barbui

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Citations

Nov 30, 2019·Advances in Hematology·Anthi BouchlaVasiliki Pappa

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