PMID: 2491953Jan 15, 1989Paper

Concomitant occurrence of an adrenal ganglioneuroma and a contralateral pheochromocytoma in a patient with von Recklinghausen's neurofibromatosis. An immunocytochemical study

Cancer
S JanssonH Ahlman

Abstract

This report presents concomitant occurrence of an adrenal ganglioneuroma and a contralateral pheochromocytoma in a patient with von Recklinghausen's disease. The patient's daughter also has cutaneous neurofibromatosis and an adrenal medullary tumor indicating that the observed "three component disease" may represent an inherited neurocristopathy. Immunocytochemically the ganglioneuroma showed a positive reaction with a tyrosinhydroxylase antiserum, but a negative reaction with a dopamine-beta-hydroxylase antiserum, suggesting the capacity of dopamine synthesis. Frequent ganglion cells were immunopositive against neuropeptide Y, but occasional ganglion cells were also positive against enkephalin and substance P. Adrenergic nerve fibers were abundant in the Schwann cell portion of the tumor, but peptide containing nerve cell processes were also demonstrated.

References

Jun 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·E Theodorsson-NorheimJ M Lundberg
Apr 1, 1967·The American Journal of the Medical Sciences·D G CameronA J Szabo
Jun 1, 1983·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J L Platt, A F Michael
Jan 1, 1962·Virchows Archiv Für Pathologische Anatomie Und Physiologie Und Für Klinische Medizin·H B TAYLOR, E B HELWIG

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Citations

Jan 22, 2013·The American Journal of Medicine·Myrella VlenterieJacques W M Lenders
Jun 1, 1989·Acta Physiologica Scandinavica·A WiganderH Ahlman
Sep 28, 2006·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Steven B MagillJoseph L Shaker
Oct 19, 1999·The Journal of Urology·M M WaltherW M Linehan

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