Concomitant overexpression of the EGFR and erbB-2 genes in renal cell carcinoma (RCC) is correlated with dedifferentiation and metastasis

International Journal of Cancer. Journal International Du Cancer
G StummR Waldherr

Abstract

Gene amplification or structural alteration of different erbB genes exerts a transforming effect in a variety of human neoplasms. Overexpression of the EGF receptor is associated with tumor initiation and progression of renal cell carcinoma (RCC). However, the role of erbB-2 in these processes remains unknown. We investigated 34 renal cell carcinomas for gene amplification and expression of the EGFR and erbB-2 genes at the mRNA and protein level and their relationship to pathological and clinical parameters. No amplification of both genes has been observed. However, high expression of the EGF receptor protein and p185erbB2 was frequent in RCC and statistically significantly related to higher tumor grades. We could demonstrate a close correlation of p185erbB2 overexpression with high EGF receptor levels. Co-overexpression of both receptor types was significantly associated with metastatic disease. Our results suggest a synergistic involvement of both EGF receptor and p185erbB2 in the progression of RCC.

References

Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·X L QuianM I Greene
Sep 9, 1992·International Journal of Cancer. Journal International Du Cancer·M RotterH Höfler
Jun 15, 1990·International Journal of Cancer. Journal International Du Cancer·J IshikawaS Kamidono
May 8, 1993·International Journal of Cancer. Journal International Du Cancer·M al-KasspoolesD G Beer

❮ Previous
Next ❯

Citations

Feb 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Min Chul ParkSunghoon Kim
Jul 21, 1999·Journal of Neurosurgery·M MaxwellN T Zervas
Aug 11, 2012·Expert Opinion on Investigational Drugs·Marine Gross-GoupilAlain Ravaud
Jul 5, 2005·Expert Opinion on Investigational Drugs·D L DrakemanP K Wallace
Jul 5, 2005·Expert Opinion on Investigational Drugs·S Eccles
Oct 15, 2008·Cancer Investigation·Susana M Campos
Sep 20, 2006·Cancer Investigation·Philip E Shaheen, Ronald M Bukowski
Jun 25, 2016·International Journal of Molecular Sciences·Szu-Chia Chen, Po-Lin Kuo
May 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alain RavaudIman El-Hariry
Jun 24, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric K RowinskyJanice Dutcher
Nov 1, 2009·Therapeutic Advances in Medical Oncology·Tanya B DorffDavid I Quinn
Mar 13, 1998·The Journal of Pathology·T J DorkinD E Neal
Nov 6, 2003·Clinical Orthopaedics and Related Research·Kristy L WeberJanet E Price
Sep 9, 2010·International Journal of Cancer. Journal International Du Cancer·Alexandre Ho-Pun-CheungEvelyne Lopez-Crapez
Jun 17, 2008·The Journal of Urology·Akio HoriguchiMasamichi Hayakawa
Apr 20, 2006·International Journal of Clinical Oncology·Shigeru KandaHiroshi Kanetake
Sep 5, 2007·Cancer Metastasis Reviews·Kristy WeberScott Kominsky
Mar 25, 2011·International Journal of Clinical Oncology·Derek ShekPrimo N Lara
Jul 31, 2013·PloS One·Yuxuan HuDavid K Y Chiu
Mar 15, 2002·Applied Immunohistochemistry & Molecular Morphology : AIMM·Manja WobusLarry S Sherman
Aug 3, 2004·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·B Ljungberg
Jun 25, 1998·International Journal of Cancer. Journal International Du Cancer·A C HobeikaH M Johnson
Jan 27, 1997·International Journal of Cancer. Journal International Du Cancer·K L LiawJ F Fraumeni
Nov 14, 1998·The American Journal of Physiology·S F LeaveyB L Margolis
Jul 22, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Linda L GarlandJoseph P Eder
Sep 28, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tanya Ahmad, Tim Eisen
Dec 9, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nancy A DawsonArif Hussain
Jun 27, 2006·Biochimica Et Biophysica Acta·Samantha J WilsonPatricia D Wilson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved