Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
H BartelinkM Pierart

Abstract

To investigate the potential gain of the concomitant use of radiotherapy and chemotherapy in improving local control and reducing the need for colostomy, a randomized phase III trial was performed in patients with locally advanced anal cancer. From 1987 to 1994, 110 patients were randomized between radiotherapy alone and a combination of radiotherapy and chemotherapy. The patients had T3-4NO-3 or T1-2N1-3 anal cancer. Radiotherapy consisted of 45 Gy given in 5 weeks, with a daily dose of 1.8 Gy. After a rest period of 6 weeks, a boost of 20 or 15 Gy was given in case of partial or complete response, respectively. Surgical resection as part of the primary treatment was performed if possible in patients who had not responded 6 weeks after 45 Gy or with residual palpable disease after the completion of treatment. Chemotherapy was given during radiotherapy: 750 mg/m2 daily fluorouracil as a continuous infusion on days 1 to 5 and 29 to 33, and a single dose of mitomycin 15 mg/m2 administered on day 1. The addition of chemotherapy to radiotherapy resulted in a significant increase in the complete remission rate from 54% for radiotherapy alone to 80% for radiotherapy and chemotherapy, and from 85% to 96%, respectively, if results are ...Continue Reading

Citations

Feb 1, 2003·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·G PéleyI Köves
Jun 5, 2003·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·E. D. ReisT. Heimann
Aug 7, 2003·Cancer Investigation·James E Gervasoni, Harold J Wanebo
Jun 7, 2003·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J E EfronJ J Nogueras
Jul 3, 2004·ANZ Journal of Surgery·Shirley WongMichael Green
Jan 18, 2006·Annual Review of Medicine·Mohamed ElshaikhAllen S Lichter
Apr 25, 2006·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S S KarandikarA G Radcliffe
Oct 27, 2006·Annals of Surgical Oncology·Eelco de BreeFrans A N Zoetmulder
Sep 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Panagiotis A KonstantinopoulosBruce J Dezube
Aug 31, 2006·Cancer Investigation·Cathy Eng
May 25, 2007·The Oncologist·Hope E Uronis, Johanna C Bendell
Apr 23, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christoph Oehler-JänneI Frank Ciernik
Apr 17, 2009·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Sabine Kathrin MaiDietmar Jörg Dinter
Sep 4, 2008·Current Oncology Reports·Jeffrey J MeyerChristopher G Willett
Aug 7, 2008·World Journal of Urology·Lance C Pagliaro, Juanita Crook
Dec 17, 2008·Wiener klinische Wochenschrift·Felix AignerAndreas Salat
Aug 26, 2009·American Journal of Clinical Oncology·Anna N RabbaniWilliam M Mendenhall
Aug 4, 2009·International Journal of Colorectal Disease·Stefan JanssenAndreas Meyer
Apr 29, 2010·Current Oncology Reports·Jeffrey MeyerBrian Czito
Aug 31, 2010·Annals of Surgical Oncology·Paola De NardiCarlo Staudacher
Dec 1, 2010·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·R CooperD Sebag-Montefiore
Feb 2, 2011·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·E Salmo, N Haboubi
Feb 2, 2011·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A G Renehan, S T O'Dwyer
Aug 10, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kåre G SunesenSøren Laurberg
Jan 27, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mahmut OzsahinPelagia G Tsoutsou
Feb 22, 2012·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·G G Grabenbauer
Feb 16, 2012·British Journal of Cancer·M P MyklebustO Dahl
Jun 19, 2012·Diseases of the Colon and Rectum·Scott R SteeleUNKNOWN Standards Practice Task Force of the American Society of Colon and Rectal Surgeons
Feb 9, 2012·International Journal of Surgical Oncology·Smith ApisarnthanaraxD Neil Hayes
Sep 27, 2012·Cancer·Robert Glynne-JonesUNKNOWN United Kingdom Coordinating Committee on Cancer Research Anal Cancer Trial Working Party
Nov 13, 2012·Techniques in Coloproctology·I GianiUNKNOWN Italian Society of Colo-Rectal Surgery
Nov 20, 2012·The Journal of Urology·Michelle J LongprePeter C Black

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