Concomitant use of blinatumomab and donor lymphocyte infusion for mixed-phenotype acute leukemia: a case report with literature review

Immunotherapy
Seren DurerFaiz Anwer

Abstract

Blinatumomab and donor lymphocyte infusion (DLI) combination is a promising cancer therapy, whereby blinatumomab might achieve an initial reduction in leukemic-cell burden using T cells, and after tumor clearance, DLI can potentially stimulate the donor immune system to achieve longer lasting remission. Here, we present a 51-year-old female with mixed phenotype acute leukemia who had a hematologic relapse 3 months after she received total body irradiation-based myeloablative allogeneic hematopoietic stem cell transplantation from an unrelated human leukocyte antigen matched (10/10) donor and achieved complete remission with minimal residual disease negativity by multi-parameter flow cytometry using the combination of blinatumomab and DLI. To the best of our knowledge, this is the first report to describe the use of blinatumomab and DLI combination therapy in the treatment of B/myeloid mixed phenotype acute leukemia.

References

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Oct 18, 2018·American Journal of Hematology·Firas El ChaerAshkan Emadi

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Citations

Nov 10, 2020·Critical Reviews in Clinical Laboratory Sciences·Claire AndrewsMark Minden
Jan 13, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Federico LussanaAlessandro Rambaldi
Feb 6, 2021·Current Oncology Reports·Thomas B Alexander, Etan Orgel
Jun 3, 2021·International Journal of Molecular Sciences·Nataša TešićUrban Švajger
Jul 14, 2021·British Journal of Haematology·Jack BartramAjay Vora

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Methods Mentioned

BETA
bone
biopsy
flow cytometry
flow
PCR

Clinical Trials Mentioned

NCT03643276
NCT02879695
NCT03541083

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