Concomitant use of mesenchymal stem cells and neural stem cells for treatment of spinal cord injury: A combo cell therapy approach

Neuroscience Letters
Seyed Mojtaba HosseiniMohmmad Reza Namavar

Abstract

with neural stem cells (NSCs) provides a hope to recover the neural damage and compensate for the lost neural structures for restoration of interrupted neural communications above and below the site of injury. However, cell-based therapy approach suffers from many biological barriers and technical caveats which severely hamper the prognosis. The biochemically-rich microenvironment at the site of spinal cord injury (SCI), the continuing neuro-degenerative process and infiltrating immune cells offer a serious barrier to the donor cells. We hypothesized that mesenchymal stem cells (MSCs) concomitantly delivered with NSCs would significantly enhance the effectiveness of cell-based therapy for SCI. In a rodent model of SCI (n = 15 animals/group), MSCs labeled with PKH67 (green fluorescence dye) were delivered on day1 after SCI whereas the same animals were treated with NSCs during the subacute phase on day3 (group-5). In comparison with untreated control (group-1), sham group (without cell treatment; group-2), MSCs alone (group-3) and NSCs alone treated animals (group-4), the combined cell treated animals (group-5) showed significantly higher homing of cells at the site of injury during in vivo imaging. Caspase-3 activity was lower ...Continue Reading

Citations

Aug 27, 2018·Journal of Cellular Biochemistry·Seyed Mojtaba HosseiniZahra Abbasi
Apr 21, 2019·Journal of Cellular Physiology·Atiyeh MohammadshiraziSahar Kiani
Feb 15, 2020·Current Stem Cell Research & Therapy·Samira AsgharzadeFatemeh Forouzanfar
Jul 6, 2019·Current Medicinal Chemistry·Shuaimeng GuanJingan Li

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