Concomitant use of opioid medications with triptans or serotonergic antidepressants in US office-based physician visits

Drug, Healthcare and Patient Safety
Kyle C MolinaDavid A Sclar

Abstract

Opioids are not recommended for routine treatment of migraine because their benefits are outweighed by risks of medication overuse headache and abuse/dependence. A March 2016 US Food and Drug Administration (FDA) safety communication warned of the risk of serotonin syndrome from using opioids concomitantly with 5-hydroxytryptamine receptor agonists (triptans) or serotonergic antidepressants: selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs). Epidemiological information about co-prescribing of these medications is limited. The objective of this study was to estimate the nationwide prevalence of co-prescribing of an opioid with a serotonergic antidepressant and/or triptan in US office-based physician visits made by 1) all patients and 2) patients diagnosed with migraine. National Ambulatory Medical Care Survey (NAMCS) data were obtained for 2013 and 2014. Physician office visits that included the new or continued prescribing of ≥1 opioid medication with a triptan or an SSRI/SNRI were identified. Co-prescribed opioids were stratified by agent to determine the proportion of co-prescriptions with opioids posing a higher risk of serotonergic agonism (meperidine, tapentadol, and tr...Continue Reading

Citations

May 28, 2019·Brain : a Journal of Neurology·Peter J GoadsbyCharly Gaul
Nov 2, 2019·Women & Health·Conisha CooperDenis Antoine
Sep 9, 2020·Expert Review of Neurotherapeutics·Paolo Martelletti
Oct 22, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Sarah T StahlJordan F Karp
Oct 30, 2020·Journal of Managed Care & Specialty Pharmacy·Meg Franklin, Eric Druyts

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BETA
pharmacotherapy

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