Concomitant variations of gastric tone and duodenal motility in humans: results of a placebo-controlled study assessing octreotide and sumatriptan

Scandinavian Journal of Gastroenterology
Guillaume SavoyePhilippe Ducrotté

Abstract

To describe the concomitant effects of octreotide and sumatriptan on fundic tone and duodenal phase III activity. A double-blind study was performed in nine volunteers, studied for 2 h after receiving 50 microg octreotide, 6 mg sumatriptan or placebo. Fundic tone variations were assessed by barostat while antroduodenal motility was studied concomitantly using manometry. A rapid increase in intrabag volume was observed in all but one subject after both sumatriptan and octreotide administration, while only two subjects exhibited a volume variation after placebo, p<0.01. A significant decrease in the number of phasic contractions was observed after octreotide, while sumatriptan reduced only wave amplitudes (p<0.05). A total of 13 concomitant duodenal phase III-like activities were observed in the duodenum after octreotide, 3 after sumatriptan and 4 after placebo, all followed by spontaneous fundic relaxation with disappearance of phasic contractions, p<0.05. Spontaneous phase III activities were different from phases III-like activities after octreotide in velocity and duration (p<0.05). Octreotide induced concomitant fundic relaxation, disappearance of phasic contractions and duodenal phase III-like activity. Sumatriptan relaxed ...Continue Reading

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Mar 3, 2005·Journal of Gastroenterology and Hepatology·Guillaume SavoyePhilippe Ducrotté
Jun 4, 2005·Scandinavian Journal of Gastroenterology·Guillaume SavoyePhilippe Ducrotté

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Citations

Nov 28, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R RosenS Nurko
Jan 22, 2021·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Haruka SekiyaIchiro Sakata

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