Apr 22, 2020

Discovery of a role for Rab3b in habituation and cocaine induced locomotor activation in mice using heterogeneous functional genomic analysis

BioRxiv : the Preprint Server for Biology
J. A. BubierElissa J Chesler

Abstract

Substance use disorders are prevalent and present a tremendous societal cost but the mechanisms underlying addiction behavior are poorly understood and few biological treatments exist. One strategy to identify novel molecular mechanisms of addiction is through functional genomic experimentation. However, results from individual experiments are often noisy. To address this problem, the convergent analysis of multiple genomic experiments can prioritize signal from these studies. In the present study, we examine genetic loci identified in the recombinant inbred (BXD RI) genetic reference population that modulate the locomotor response to cocaine. We then applied the GeneWeaver software system for heterogeneous functional genomic analysis to integrate and aggregate multiple studies of addiction genomics, resulting in the identification of Rab3b, as a functional correlate of the locomotor response to cocaine in rodents. This gene encodes a member of the RAB family of Ras-like GTPases known to be involved in trafficking of secretory and endocytic vesicles in eukaryotic cells. The convergent evidence for a role of Rab3b was included co-occurrence in previously published genetic mapping studies of cocaine related behaviors; methampheta...Continue Reading

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Mentioned in this Paper

Study
Fluctuation
Arousal
Participant
Brain Function
FMRI
Literature
Brain Activity
Analysis
Interphase Cell

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