Concordance and heritability of multiple sclerosis in Finland: study on a nationwide series of twins

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
H KuusistoI Elovaara

Abstract

To evaluate the changes in the multiple sclerosis (MS) concordance in twins, and the contribution of genetic and environmental factors to the aetiology of MS in Finland. Both genes and the environment contribute to the development of MS. A well-conducted twin study is an excellent means to assess the relative contribution of heritability and environmental factors. Multiple sclerosis concordance was assessed for 10 Monozygotic and 14 dizygotic twin pairs using pairwise and probandwise concordance rates. The tetrachoric correlations in liability to disease for twin pairs were computed and a polygenic multifactorial model was used to estimate heritability. The pairwise concordance for MZ twins was 30% and for the DZ twins 14.3%, compared with 30% for MZ and 0% for DZ 20 years ago. The corresponding probandwise concordance rates were 46.2% and 25%. The genetic variance (heritability) was 15.3% (95% Cl 0.0-77.6), the common environmental variance 73.7% (95% Cl 14.1-93.9) and the unique environmental variance 11.1% (95% Cl 2.3-30.0). As the concordance of MS in DZ twins has increased during the past two decades and the heritability estimate is low, it seems that the reported increase in MS incidence in Finland is mainly caused by env...Continue Reading

References

Jan 1, 1978·Human Heredity·S SarnaM Koskenvuo
Apr 1, 1991·Brain : a Journal of Neurology·D E BulmanG C Ebers
Oct 1, 1987·Neurology·E KinnunenK Aho
Dec 25, 1986·The New England Journal of Medicine·G C EbersT Grey
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Apr 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·J W ThorpeD H Miller
Jan 1, 1994·Neurology·C J MumfordD A Compston
Mar 1, 1993·Annals of Neurology·A D SadovnickT J Murray
May 1, 1997·QJM : Monthly Journal of the Association of Physicians·C H Hawkes
Dec 22, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A Compston
Mar 10, 2001·Acta Neurologica Scandinavica·M L SumelahtiM Hakama
Dec 17, 2002·Autoimmunity·Bernadette KalmanThomas P Leist
Jan 23, 2003·Twin Research : the Official Journal of the International Society for Twin Studies·Jaakko Kaprio, Markku Koskenvuo
Oct 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·C J WillerUNKNOWN Canadian Collaborative Study Group
Nov 20, 2003·Twin Research : the Official Journal of the International Society for Twin Studies·Daniëlle PosthumaDorret I Boomsma
Oct 1, 2005·Multiple Sclerosis : Clinical and Laboratory Research·Thomas HansenHenrik Brønnum-Hansen
Oct 1, 2005·Multiple Sclerosis : Clinical and Laboratory Research·T HansenK O Kyvik
Oct 22, 2005·Annals of Neurology·Giovanni RistoriMarco Salvetti
May 11, 2006·Annals of Neurology·Talat IslamThomas M Mack
Oct 21, 2006·Lancet Neurology·Sarah-Michelle OrtonUNKNOWN Canadian Collaborative Study Group
Jan 27, 2007·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Jaakko Kaprio

❮ Previous
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Citations

Jun 23, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A HietaharjuE Moilanen
Oct 12, 2012·Biologics : Targets & Therapy·Judith M Greer, Pamela A McCombe
Mar 15, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Majid ShahbaziAzam Rshaidbaghan
May 6, 2014·Frontiers in Neuroendocrinology·S T NgoP A McCombe
Jul 21, 2016·Immunologic Research·María-Teresa ArangoYehuda Shoenfeld
Jan 15, 2015·Multiple Sclerosis : Clinical and Laboratory Research·Corrado FagnaniGiovanni Ristori
Jun 2, 2009·Multiple Sclerosis : Clinical and Laboratory Research·C H Hawkes, A J Macgregor
Jan 9, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Ester Canto, Jorge R Oksenberg
Nov 21, 2012·Nature Reviews. Neurology·Marcus W KochOlga Kovalchuk
Mar 2, 2010·Expert Review of Neurotherapeutics·Klaus Lauer
Mar 2, 2018·Evolution, Medicine, and Public Health·Riley M Bove
Nov 8, 2020·Biochemical Genetics·Concetta ScazzoneMarcello Ciaccio
Jan 25, 2020·Neuroscience and Biobehavioral Reviews·M C BuscarinuG Ristori
Dec 23, 2020·International Journal of Molecular Sciences·Adolfo I Ruiz-BallesterosUlises de la Cruz-Mosso
Mar 23, 2021·PloS One·Douglas S GoodinNicolas Vince

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