Concordance between Aspergillus-specific precipitating antibody and IgG in allergic bronchopulmonary aspergillosis

Allergology International : Official Journal of the Japanese Society of Allergology
Kazuki HaradaKoichiro Asano

Abstract

Several serological tests for specific precipitin or IgG are available to demonstrate type III hypersensitivity reactions to Aspergillus species and are essential for infectious fungal disease diagnosis. These assays are also important for allergic bronchopulmonary aspergillosis (ABPA) diagnosis; however, their concordance in ABPA was not well studied. Fifty-two ABPA patients diagnosed based on ISHAM criteria were enrolled. Precipitins and IgG specific to Aspergillus fumigatus, Aspergillus niger, Aspergillus flavus, or Aspergillus terreus were measured using Ouchterlony double immunodiffusion tests and ImmunoCAP method, respectively. A. fumigatus-specific IgG was also determined using complement-fixation (CF) method. Forty-eight percent of cases were double-positive for A. fumigatus-specific precipitin and IgG (ImmunoCAP), whereas 3 (6%) and 14 (28%) cases were positive for precipitin or IgG alone, respectively. Kappa coefficient between these measurements was 0.32, suggesting poor concordance. Double-positive cases were more likely to present: Aspergillus sp. in sputum culture, lower pulmonary functions, peripheral blood eosinophilia, higher total IgE and A. fumigatus-specific IgG titer than precipitin-negative cases. A. fumig...Continue Reading

Citations

Apr 5, 2019·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Kazunobu KuwabaraTakahiko Horiguchi
Dec 10, 2020·Clinical and Translational Allergy·W Garth RapeportDavid W Denning
Sep 14, 2020·The Journal of Allergy and Clinical Immunology·Koichiro AsanoUNKNOWN Japan ABPM Research Program
Jun 12, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Valliappan Muthu, Ritesh Agarwal
Jun 12, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Murat Türkİnsu Yılmaz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.