Concordance between inflammation at physical examination and on MRI in patients with early arthritis

Annals of the Rheumatic Diseases
A KrabbenA H M van der Helm-van Mil

Abstract

MRI is increasingly used to measure inflammation in rheumatoid arthritis (RA) research, but the correlation to clinical assessment is unexplored. This study determined the association and concordance between inflammation of small joints measured with MRI and physical examination. 179 patients with early arthritis underwent a 68 tender joint count and 66 swollen joint count and 1.5T MRI of MCP (2-5), wrist and MTP (1-5) joints at the most painful side. Two readers scored synovitis and bone marrow oedema (BME) according to the OMERACT RA MRI scoring method and assessed tenosynovitis. The MRI data were first analysed continuously and then dichotomised to analyse the concordance with inflammation at joint examination. 1790 joints of 179 patients were studied. Synovitis and tenosynovitis on MRI were independently associated with clinical swelling, in contrast to BME. In 86% of the swollen MCP joints and in 92% of the swollen wrist joints any inflammation on MRI was present. In 27% of the non-swollen MCP joints and in 66% of the non-swollen wrist joints any MRI inflammation was present. Vice versa, of all MCP, wrist and MTP joints with inflammation on MRI 64%, 61% and 77%, respectively, were not swollen. BME, also in case of severe l...Continue Reading

References

Jan 20, 2004·Arthritis and Rheumatism·Esmeralda T H MolenaarBen A C Dijkmans
Jan 14, 2005·Annals of the Rheumatic Diseases·M ØstergaardP Conaghan
Jul 20, 2010·Rheumatology·Diederik P C de RooyAnnette H M van der Helm-van Mil
Mar 3, 2011·The Journal of Rheumatology. Supplement·Pedro M M C MachadoDésirée M van der Heijde
Oct 17, 2012·Nature Reviews. Rheumatology·Annette H M van der Helm-van Mil

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Citations

Apr 26, 2015·Annals of the Rheumatic Diseases·W B van den BoschA H M van der Helm-van Mil
Aug 2, 2015·Annals of the Rheumatic Diseases·Wei LuoHongbo He
Sep 1, 2015·Rheumatology International·David Vega-MoralesMario Alberto Garza-Elizondo
Apr 12, 2016·Journal of Medical Imaging and Radiation Oncology·Regina M Taylor-GjevreHaron Obaid
Dec 4, 2019·Expert Review of Clinical Immunology·Elizabeth M A Hensor, Philip G Conaghan
Mar 2, 2016·Current Opinion in Rheumatology·Ashish J MathewPhilip G Conaghan
Jul 5, 2017·European Radiology·Takeshi FukudaKunihiko Fukuda
Apr 5, 2020·Arthritis Research & Therapy·Yousra J DakkakAnnette H M van der Helm-van Mil
Jul 31, 2014·Annals of the Rheumatic Diseases·A KrabbenA H M van der Helm-van Mil
Aug 25, 2015·Arthritis Research & Therapy·Lukas MangnusAnnette H M van der Helm-van Mil
Mar 18, 2021·Der Radiologe·Matthias Bollow
Sep 1, 2021·Annals of the Rheumatic Diseases·Sascha L HeckertTom W J Huizinga

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