PMID: 11920812Mar 29, 2002Paper

Concordance between semen-derived HIV-1 proviral DNA and viral RNA hypervariable region 3 (V3) envelope sequences in cases where semen populations are distinct from those present in blood

Journal of Medical Virology
Rebecca Curran, Jonathan K Ball

Abstract

Sequence analysis of the third hypervariable region (V3) of the envelope gene of the HIV-1 was carried out on HIV proviral and viral populations present in blood and semen. Phylogenetically distinct populations of virus were observed in three of the 10 patients analysed. Although the majority of the viruses were predicted to have an R5 phenotype, amino acid differences between blood and semen-derived virus and provirus sequences were observed at sites previously shown to affect cell tropism. Importantly, the semen proviral population was representative of that observed for cell-free virus. This indicates that seminal fluid mononuclear cells are possible sources for the cell-free virus in found in semen.

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Citations

Nov 11, 2011·PloS One·Samatchaya BoonchawalitMasanori Kameoka
Nov 22, 2014·The Journal of Infectious Diseases·Laurent HouzetNathalie Dejucq-Rainsford
Nov 24, 2007·Gynécologie, obstétrique & fertilité·A Le Tortorec, N Dejucq-Rainsford
Jun 18, 2009·International Journal of Andrology·A Le Tortorec, N Dejucq-Rainsford
Jul 23, 2004·Evolution; International Journal of Organic Evolution·Rafael SanjuánSantiago F Elena

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