Concordance for Parkinson's disease in twins: A 20-year update

Annals of Neurology
Samuel M GoldmanCaroline M Tanner

Abstract

During the 1990s, we estimated the genetic contribution to Parkinson's disease risk in a large, population-based twin registry. Because many unaffected twins were still alive, previous concordance estimates were based on incomplete information. Ninety-five percent of twins are now deceased. Here, we update concordance and heritability through 2015 using National Death Index data. In total, we identified 30 concordant and 193 discordant pairs. Proband-wise concordance was 0.20 in monozygotic and 0.13 in dizygotic pairs. Heritability was 0.27 overall, 0.83 in pairs diagnosed ≤50, and 0.19 in pairs diagnosed >50. High concordance in dizygotic twins suggests shared effects of early childhood environment. Ann Neurol 2019;85:600-605.

References

Jan 1, 1992·Movement Disorders : Official Journal of the Movement Disorder Society·J W LangstonR Watts
Jan 29, 1999·Archives of Neurology·D J GelbS Gilman
Feb 3, 1999·JAMA : the Journal of the American Medical Association·C M TannerJ W Langston
Jan 10, 2002·Journal of Clinical Epidemiology·Alexis ElbazWalter A Rocca
Dec 8, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Joyce C PressleyRichard Mayeux
Sep 16, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Michael Y ShinoLorene M Nelson
Apr 13, 2011·Neurobiology of Aging·Karin WirdefeldtNancy L Pedersen
Aug 16, 2012·Human Molecular Genetics·Margaux F KellerUNKNOWN Wellcome Trust Case Control Consortium 2 (WTCCC2)
Sep 10, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·J A ObesoA J Stoessl

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Citations

Feb 23, 2020·Journal of Parkinson's Disease·Maya R SilverSusan Searles Nielsen
May 16, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Connie MarrasSamuel M Goldman
Aug 21, 2019·Translational Neurodegeneration·Shirley Yin-Yu PangShu-Leong Ho
Feb 7, 2020·Brain : a Journal of Neurology·Samanta MazzettiGianni Pezzoli
Sep 26, 2020·Frontiers in Molecular Neuroscience·Naila Kuhlmann, Austen J Milnerwood
Jul 30, 2019·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Margaret GatzDavid A Butler
Sep 24, 2020·NPJ Parkinson's Disease·Steven E PierceGerhard A Coetzee
Oct 24, 2020·Annals of Neurology·Marija Dulovic-MahlowKatja Lohmann
Oct 27, 2020·Journal of Parkinson's Disease·Yi-Hsuan LiuXiang Gao
Nov 18, 2019·Clinics in Geriatric Medicine·David K SimonPatrik Brundin
Mar 16, 2021·Journal of Parkinson's Disease·Michael X HendersonVirginia M Y Lee
May 9, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Peter A BarbutiUNKNOWN MDS Scientific Issues Committee
May 24, 2020·Neurobiology of Disease·Eftychia BellouValentina Escott-Price
May 20, 2021·PloS One·Srishti ShresthaDale P Sandler
Jul 3, 2021·Genes·Jacob Oliver Day, Stephen Mullin
Oct 7, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Lasse PihlstrømOle A Andreassen

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