Concordance of biopsy and prostatectomy diagnosis of intraductal and cribriform carcinoma in a prospectively collected data set

Histopathology
Mehdi MasoomianTheodorus H van der Kwast

Abstract

Intraductal and cribriform carcinoma of the prostate are increasingly recognised as independent prognosticators of poor outcome, both in prostate biopsies and surgical specimens. We studied the concordance of biopsy and prostatectomy diagnosis for these two subpathologies in relationship with pathological stage. Mandatory synoptic reporting of intraductal and cribriform carcinoma in prostate biopsies and prostatectomy specimens was adopted by two academic institutions in November 2015. Synoptic reports of 245 biopsy and corresponding prostatectomy specimens were interrogated to determine the prevalence of intraductal and cribriform carcinoma. Sensitivity and specificity were determined, with prostatectomy diagnosis as the gold standard. Associations with pathological stage as primary outcome parameter were determined using univariable and multivariable logistic regression analysis. Prevalence of the combination of intraductal and cribriform carcinoma was 26.9% in biopsies and 51.8% in prostatectomy specimens. Sensitivity and specificity at biopsy were 47.2% and 94.9%, respectively. Intraductal and cribriform carcinoma at biopsy were associated with advanced pathological stage independent of grade (P = 0.013). Among patients wit...Continue Reading

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Citations

Jul 21, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Eva HollemansGeert J L H van Leenders
Mar 7, 2020·Science Translational Medicine·Mitchell G LawrenceGail P Risbridger
Jun 27, 2020·Archives of Pathology & Laboratory Medicine·Jonathan I EpsteinKiril Trpkov
Mar 30, 2021·Annals of Diagnostic Pathology·Kenneth A IczkowskiLars Egevad
Oct 21, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Michelle R DownesTheodorus H van der Kwast
Jun 1, 2021·Urology·Amanda B HesterbergPaula J Hurley
Jul 18, 2021·Current Oncology Reports·Bryden ConsidineMichael E Hurwitz
May 18, 2021·The American Journal of Surgical Pathology·Theodorus H van der KwastLars Egevad
Jul 16, 2021·The American Journal of Surgical Pathology·Hemamali SamaratungaLars Egevad

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