Concordance rate between HER2 immunohistochemistry and in situ hybridization in gastric carcinoma: systematic review and meta-analysis

The International Journal of Biological Markers
Jung-Soo PyoWoo Ho Kim

Abstract

The aim of this study was to investigate the diagnostic accuracy of HER2 immunohistochemistry (IHC) in gastric carcinoma (GC) through a systematic review, meta-analysis and diagnostic test accuracy review. The current study included 12,679 GC cases and 181 subsets in 45 eligible studies. We performed concordance analysis between HER2 IHC and in situ hybridization (ISH) in GC. Diagnostic test accuracy was analyzed and the area under the curve (AUC) on the summary receiver operating characteristic (SROC) curve was calculated. HER2 amplification rates were 3.0%, 31.8%, and 93.0% in the IHC score 0/1+, 2+, and 3+ groups, respectively. The concordance rates between IHC and ISH were 0.969 (95% confidence interval [CI] 0.962-0.975), 0.393 (95% CI 0.331-0.458) and 0.915 (95% CI 0.882-0.939) in the HER2 IHC score 0/1+, 2+, and 3+ groups, respectively. For all the HER2 IHC score groups, the positive rates were higher in the silver ISH (SISH) subgroup than in the fluorescence ISH (FISH) and chromogenic ISH (CISH) subgroups. In diagnostic test accuracy review, the pooled sensitivity and specificity were 0.86 (95% CI 0.84-0.87) and 0.91 (95% CI 0.90-0.91). The AUC on SROC curve was 0.958. However, there was no significant difference in the ...Continue Reading

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Citations

Oct 30, 2016·The International Journal of Biological Markers·Jung-Soo PyoKyeongmee Park
Oct 30, 2016·The International Journal of Biological Markers·Jung-Soo PyoJin Hee Sohn
Sep 28, 2016·World Journal of Gastroenterology : WJG·Nicola Fusco, Silvano Bosari
May 10, 2017·The International Journal of Biological Markers·Young San KoJung-Soo Pyo
Nov 5, 2020·Journal of Oncology·Catalin Bogdan SatalaSimona Gurzu

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