PMID: 2510165Nov 1, 1989Paper

Concordant evolution of coding and noncoding regions of DNA made possible by the universal rule of TA/CG deficiency-TG/CT excess

Proceedings of the National Academy of Sciences of the United States of America
T Yomo, S Ohno

Abstract

The universal rule of TA/CG deficiency-TG/CT excess previously proposed as the construction principle of coding sequences applies to noncoding regions of the gene as well. Analysis of a 1989-base-long gene sequence for mouse immunoglobulin gamma 2a heavy-chain constant region as well as the 19,002-base-long gene sequence for human serum albumin revealed deficiency and overabundance of very similar sets of base trimers and tetramers in the coding and noncoding regions of the same gene, in spite of the fact that noncoding regions were considerably richer in A + T. Inasmuch as this universal rule does not discriminate one strand of DNA double helix from another, two complementary DNA strands of the entire gene maintained nearly perfect symmetry. That is to say, the degrees of excesses, deficiencies of the 64-base trimers remained nearly identical between two complementary strands, and this symmetry was only slightly disturbed in the coding region. It would thus appear that the universal rule as an intrinsic force has been exerting far greater influence than natural selection in the evolution of genes.

References

Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S Ohno

❮ Previous
Next ❯

Citations

Feb 1, 1991·Electrophoresis
Mar 1, 1995·Journal of Molecular Evolution·H MustoF Alvarez
May 1, 1994·Journal of Molecular Evolution·E C Bronson, J N Anderson
Dec 1, 1993·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·S RodinA Rodin
Dec 4, 2009·Journal of Molecular Evolution·Andrei S RodinCharles W Carter
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S Ohno, T Yomo
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S Ohno
May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·T YomoH Okada
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S RodinA Rodin
Dec 1, 1993·Current Opinion in Genetics & Development·S Ohno
Jun 5, 2004·Gene·Kamel Jabbari, Giorgio Bernardi
Jul 1, 1991·Experimental Parasitology·M ParsonsB L Smiley
Aug 7, 1991·Journal of Theoretical Biology·A A TsonisP A Tsonis
Aug 8, 2006·Genomics·Kohji OkamuraStephen W Scherer
Jul 15, 2016·FEMS Microbiology Letters·Jose F Garcia-Mazcorro, Jose R Barcenas-Walls
Feb 1, 1991·Electrophoresis·S Ohno, T Yomo
Feb 1, 1996·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·A A TsonisP A Tsonis
Sep 10, 2020·Viruses·Huiguang WuJingwen Zhao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved