PMID: 8590315Feb 1, 1995Paper

Concurrence of high levels of interferons alpha and beta in cord and maternal blood and simultaneous presence of interferon in trophoblast in an African population

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
P EbbesenA Nyongo

Abstract

A high concentration of interferon-alpha (IFN-alpha) (> 5 U/ml) in cord blood was used as the criterion for establishing our study group. In a collection from deliveries by 269 Kenyan women, 16 such cord samples with matching maternal blood and placental biopsies were identified. These 16 were studied in detail together with 23 randomly selected among those with low cord IFN-alpha levels. The levels of IFN- in retal blood correlated with levels in their mothers for both IFN-alpha and beta but not for IFN-gamma. IFN-alpha was furthermore demonstrated in villous and decidual trophoblast from 15 (94%) placentae from donors with high IFN-alpha in the cord blood but not in the placenta of any low IFN level donors. In contrast, IFN-beta was not demonstrated in any placenta. These observations suggest simultaneous IFN induction in the three compartments, transplacental IFN transport, or trophoblast production of IFN to both circulations. Looking for IFN inducers, we did serologic tests for nonspecific indicators of inflammation and for specific virus and protozoan infections, but these showed no relation to elevated IFN levels. Immunohistology also revealed no evidence of a number of placental infections. The cause of the high levels ...Continue Reading

References

Feb 1, 1992·AIDS Research and Human Retroviruses·M L FrancisH E Gendelman
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Citations

Oct 7, 2000·Bulletin of Experimental Biology and Medicine·S A Sel'kovA V Selyutin
Jan 1, 1996·AIDS Research and Human Retroviruses·V ZacharP Ebbesen
Mar 31, 2016·Current Opinion in Infectious Diseases·Erica L Johnson, Rana Chakraborty
Mar 17, 2004·Reproduction, Fertility, and Development·Snjezana Zidovec LepejRenata Mazuran
Jan 23, 2008·Journal of Clinical Gastroenterology·Delia Maria PaternosterAnnarosa Floreani

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