Concurrent antiglomerular basement membrane disease and immune complex glomerulonephritis

Renal Failure
Zhao CuiHai-yan Wang

Abstract

Antiglomerular basement membrane (GBM) disease is characteristically described with linear deposition of IgG along GBM. However, the concurrent glomerular immune complex deposition was not rare and might be contributed to the development of anti-GBM disease. In the current series, glomerular immune complexes were identified in 10 of 47 patients who presented with renal-biopsy-proven anti-GBM disease. Six of the 10 patients complicated with a well-documented glomerulonephritis, including two patients with membranous nephropathy, one patient with IgA nephropathy, one patient with membranoproliferative glomerulonephritis, one patient with Schonlein-Henoch nephritis, and one patient with hepatitis B virus associated membranous nephritis. The other four patients had immune complexes with IgG or IgM predominance deposited in glomerular mesangium without a well-documented glomerulonephritis. Clinical and pathological data of patients with immune complex deposition (n = 10) were compared with those of patients with anti-GBM disease alone (n = 37). There was no significant difference in age, gender, clinical and pathological manifestations, and renal outcome between the two groups. In general, the association of glomerular immune comple...Continue Reading

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Citations

Sep 10, 2011·Journal of the American Society of Nephrology : JASN·Amanda Walton BasfordAgnes B Fogo
Nov 1, 2013·CEN Case Reports·Takeshi YamamotoMegumu Fukunaga
Sep 17, 2019·Journal of Pathology and Translational Medicine·Kwang-Sun SuhMin-Kyung Yeo
Mar 17, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Min ChenMing-Hui Zhao
Jul 20, 2011·Nature Reviews. Nephrology·Zhao Cui, Ming-Hui Zhao
Dec 21, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Zhao CuiMing-hui Zhao

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